Results 191 to 200 of about 2,083,504 (286)

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

Effects of maternal exposure to an adsorbed acellular diphtheria-tetanus-pertussis (reduced-dose) combined vaccine on prenatal and postnatal development in Sprague-Dawley rats: a preclinical study. [PDF]

Front Immunol
Kong W, Chu H, Gu Q, Ma Y, Cai L, Li J, Wang X, Ji Q, Wen J, Gao N, Ji G, Hu W, Zhao T, Ping L, Fu Y, Li Y, Gong T, Jin Y, Yang Y, Fu Y, Qin X, Zheng H, Yang J, Liang J.   +23 more
europepmc   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Meteorin-like controls metabolic adaptations and physiological myocardial remodeling in pregnancy and lactation. [PDF]

Front Endocrinol (Lausanne)
Blasco-Roset A, Ruperez C, Navarro-Gascon A, Godoy-Nieto FJ, Crispi F, Crovetto F, Gratacós E, Villarroya F, Quesada-López T, Planavila A.   +9 more
europepmc   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Correction: Breast milk Δ9-tetrahydrocannabinol in cannabis users during the postpartum period: correlation between breast milk, maternal urine and saliva samples during early lactation. [PDF]

Front Psychiatry
Sandonís M, Brik M, Ramirez C, Castellote L, Creus A, Parramón G, Suy A, Ramos-Quiroga JA, Palma-Álvarez RF, Daigre C.   +9 more
europepmc   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Impact of Neonatal Intensive Care Unit (NICU) Environment on Maternal Breast Milk Utilization: : A Retrospective Study. [PDF]

Dela J Public Health
Heckman L, Flynn K, Mackley A, Kovatis K.   +3 more
europepmc   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Effect of extended close-up period duration on peripartum behavior, udder morphology, body condition score, and early lactation yield in primiparous Holstein cows. [PDF]

Vet World
Najjar A, Dougaz H, Halawa W, Khalil M, M'Hamdi N.   +4 more
europepmc   +1 more source