Results 141 to 150 of about 101,713 (298)
Advanced Science, EarlyView.ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei +11 more
wiley +1 more source
Post weaning altrenogest use in sows: follicle growth, endocrine profiles and subsequent fertility
, 2011 A severe negative energy balance during first lactation may result in poor reproductive performance in the second litter. Allowing the sow recovery time after weaning by inseminating the sow the second estrus after weaning (skip a heat) improves ...
van Leeuwen, J.J.J. +1 more
core
Advanced Science, EarlyView.Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang +6 more
wiley +1 more source
DairyHyperketonemia (HYK) is a common disorder in high-producing dairy cows, resulting in significant economic losses. Defined by elevated beta-hydroxybutyrate (BHB; ≥1.2 mmol/L) without clinical signs, HYK is often considered a gateway disease, predisposing ...
Mahmoud H. Emam +3 more
doaj +1 more source
Reliability of Averages of Different Numbers of Lactation Records for Comparing Dairy Cows
Journal of Dairy Science, 1945 Summary Formulae which describe the relative reliability for prediction purposes of averages based on different numbers of records have been presented. The major increase in reliability occurs when a second record becomes available to use along with the first.
openaire +1 more source
Mammary gland cell content during various phases of lactation
, 1962 Deoxyribonucleic acid (DNA) was used as an index of the cellular state of the rat mammary gland in late pregnancy ( day 20) and early ( day 1), intense ( day 14), and declining ( day 28) lactation.
Richard C. Moon
core +1 more source
m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis
Advanced Science, EarlyView.This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang +26 more
wiley +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, EarlyView.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
Advanced Science, EarlyView.An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu +11 more
wiley +1 more source
Animal Production: Indonesian Journal of Animal Production, 2009 The research was conducted at Balai Besar Pembibitan Ternak Unggul Sapi Perah (BBPTU-SP) Baturraden, Purwokerto, Central Java. The aims of this research were to study: (1) Breeding Value among test day record at first, second and third lactations on milk
Karnaen Karnaen, J Arifin
doaj