Results 41 to 50 of about 8,772,762 (291)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Short communication: Goat colostrum quality: Litter size and lactation number effects [PDF]

Journal of Dairy Science, 2013
The quality of colostrum of Murciano-Granadina goats was studied to establish the transition period and the time when milk can be marketed. Forty-three dairy goats were used: 19 primiparous (15 single births; 4 multiple births) and 24 multiparous (10 single births; 14 multiple births).
Romero Rueda, Tamara, Beltrán Martínez, Mª Carmen, Rodríguez Garcia, Martín, Molina Pons, Mª Pilar, Marti-De Olives A.   +4 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The importance of hoof health in dairy production

Czech Journal of Animal Science, 2019
The objective of this study was to evaluate the association of hoof health on reproduction and production performance, somatic cell count, and longevity in dairy cattle.
Lenka Krpálková, Victor E. Cabrera, Ludmila Zavadilová, Miloslava Štípková   +3 more
doaj   +1 more source

Influence of milk production records on the estimation of typical and extended curve lactation parameters in local goats under grazing management

Indian Journal of Animal Sciences, 2020
The effect of measure number of milk production (MP) on the estimation of parameters in typical and extended lactations curve parameters of local goats was evaluated.
GLAFIRO TORRES-HERNÁNDEZ, JORGE A. MALDONADO-JÁQUEZ, HOMERO SALINAS-GONZÁLEZ, LORENZO DANILO GRANADOS-RIVERA, FRANCISCO J. PASTOR-LÓPEZ, HUMBERTO VAQUERA-HUERTA, YURIDIA BAUTISTA-MARTÍNEZ   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

A Note on the Length of Lactation and the Number of Consecutive Days in Average to Obtain More Typical Lactation Curve in Dairy Cattle

Nihon Chikusan Gakkaiho, 1977
前報において,乳量検定開始後43週までの週平均日量を用いて,乳牛の泌乳曲線にWOODの提示した模型(Yn=A•nB•e-Cn, Ynはn週目の平均日量業であり,A, B, Cは定数)を適合させたところ,典型的な泌乳曲線がB>0, C>0であるのに対して,B 0の非典型的な泌乳曲線が約1/4推定された.本研究において,この難点を克服する1つの手法として,10日,7日,5日,3日間の平均日量あるいは毎日の乳量と,模型を適合させる期間を約305日,240日,180日,150日,120日あるいは90日と変えて推定し,非典型的な泌乳曲線の数に基づいて,泌乳曲線を推定するためのより適切な平均日量と期間について検討した.資料は前報と同じ187のホルスタイン種の1産目の毎日の搾乳記録である ...
SHIMIZU, Hiroshi, UMROD, Sanoh
openaire   +2 more sources

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source