Results 51 to 60 of about 101,713 (298)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

COMPARATIVE PERFORMANCE OF SAHIWAL COWS AT THE LIVESTOCK EXPERIMENT STATION BAHADURNAGAR, OKARA VS PATADAR’S HERD [PDF]

Pakistan Veterinary Journal, 2006
The data on 3434 records for lactation milk yield and lactation length and 2314 records for dry period of Sahiwal cows maintained at the Livestock Experiment Station (LES), Bahadurnagar, Okara, Pakistan and its Patadars during 1986-2000 were analyzed by ...
S. U. REHMAN, M. AHMAD AND M. SHAFIQ1
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The Effect of The Season and Lactation Number on The Composition and Quality Of Holstein Cattle Raw Milk [PDF]

, 2021
The aim of this study was to determine the Somatic Cell Count of raw milk which obtained from Holstein-Frisian dairy cow milk and determine the effects of season and lactation number on the composition and quality of raw milk. Milk samples were collected
Tuna, Yahya Tuncay, Ahmet Refik ÖNAL, Yahya Tuncay TUNA, Mahmut ÖZKAN, Özkan, Mahmut, Önal, Ahmet Refik   +5 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Impact of Dam Lactation Number on Colostrum Quality, Calf Growth, and Economic Performance in Holstein Cows

Veterinary Sciences
This study investigated the associations among dam lactation number, passive immunity transfer, internal parasite burden, and weaning performance in female calves.
Andrea García-Mendoza, Milagros González-Hernández, Delia X. Vega-Manriquez, Erika Félix-Santiago, María del Refugio Pérez-Barba, César A. Rosales-Nieto   +5 more
doaj   +1 more source

Milk Yield and Composition, Technological Properties and Homeostasis Indices at Different Lactation Stages and Parities of Two Polish Dairy Goat Breeds

Acta Universitatis Cibiniensis. Series E: Food Technology, 2023
The purpose of the research was to determine the effect of breed, lactation number, and lactation stage on milk efficiency and goat milk ingredients, these being indicators of milk technological parameters and homeostasis disturbances.
Urbańska Daria Maria, Puchała Ryszard, Jarczak Justyna, Barłowska Katarzyna, Czopowicz Michał, Mickiewicz Marcin, Kaba Jarosław, Bagnicka Emilia   +7 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source