Results 181 to 190 of about 47,243 (214)

Integrated Single-Nucleus Multi-Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution. [PDF]

Adv Sci (Weinh)
Yan X, Mi X, Tan G, Li X, Zhu Z, Wei Z, Fan H, Wu Y, Shi T, Fang L, Gao Y, Wang Y, Liu J.   +12 more
europepmc   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Associations Between Feeding Management Practices Across Lactation and Goat Milk Composition in Semi-Intensive Systems: A Structural Equation Modeling Approach. [PDF]

Animals (Basel)
Alexandridis V, Malissiova E, Vasileiou N, Kantas D.   +3 more
europepmc   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Influence of postpartum disorders, parity, and season on estimated methane emissions in dairy cows in northwest of Spain. [PDF]

Vet Anim Sci
Álvarez J, Acción A, Barrionuevo R, Yáñez U, Becerra JJ, Peña AI, Cainzos J, Fouz R, Quintela LÁ.   +8 more
europepmc   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Comparative Analysis of Metabolic and Developmental Changes Across Reproductive Stages in Breeding Pigeons. [PDF]

J Poult Sci
Ziying L, Chenjiahui Z, Rongkang Z, Huilin L, Can L, Haopeng L, Guohua T, Wuhao C, Shuangyan M, Huimin C, Xingyue Q, Yantao L, Yanhua H, Wei W, Shuo Z, Yayan L, Jie P.   +16 more
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Milk Thistle Extract Enhances Lactational Performance in Primiparous Sows: A Comparative Screening of Plant-Derived Additives. [PDF]

Animals (Basel)
Wu Y, Yang L, He Z, Wang M, Zhou X, He J, Hu M.   +6 more
europepmc   +1 more source