Results 21 to 30 of about 47,243 (214)

RNA sequencing of the human milk fat layer transcriptome reveals distinct gene expression profiles at three stages of lactation. [PDF]

open access: yesPLoS ONE, 2013
Aware of the important benefits of human milk, most U.S. women initiate breastfeeding but difficulties with milk supply lead some to quit earlier than intended.
Danielle G Lemay   +5 more
doaj   +1 more source

Milk Composition of Creole Goats Raised at Different Altitudes in an Extensive Production System in Northeast Mexico

open access: yesAnimals, 2023
Goat milk composition is affected by feeding, and in semiarid rangeland, information on Creole goat milk physicochemical composition is lacking. For the fulfillment of this objective, three agroecological regions (AR) considering altitude (lowland 87 ...
Luz Y. Peña-Avelino   +4 more
doaj   +1 more source

Сomposition of cows’ butterfat in different terms after calving

open access: yesVìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ, 2010
Influence of the lactation stage on cow milk’s fatty acids composition has been studied. The lactation stage has influence on the content of biologically valuable unsaturated myristoleic, linoleic and linolenic acids.
V. V. Tsyupko
doaj   +1 more source

Human milk metabolome: Impact of gestational age, lactational stage and maternal diet

open access: yesRoczniki Panstwowego Zakladu Higieny, 2022
Human breast milk due to its unique composition and the ability to adapt to the needs of the infant, is referred to as the "gold standard". Exclusive breastfeeding is recommended for the first 6 months of a inflant's life.
Malwina Wójcik, Hanna Mojska
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Physicochemical and sensory characteristics of milk from cows in different lactation stages and calving orders

open access: yesSemina: Ciências Agrárias, 2016
Knowledge of the variation in milk composition is essential for determining milk quality, which is defined by several organoleptic properties. This study evaluated the effect of lactation stage and calving order on the physicochemical composition and ...
Mayara Leilane de Jesus Barreto   +4 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

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