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Evaluation of Modulatory Activities of Lactobacillus crispatus Strains in the Context of the Vaginal Microbiota. [PDF]

Microbiology Spectrum, 2022
It has been widely reported that members of the genus Lactobacillus dominate the vaginal microbiota, which is represented by the most prevalent species Lactobacillus crispatus, Lactobacillus jensenii, Lactobacillus gasseri, and Lactobacillus iners.
Francesca Turroni, MANCABELLI Leonardo, Gabriele Andrea Lugli   +2 more
exaly   +9 more sources

Strain-level variation among vaginal Lactobacillus crispatus and Lactobacillus iners as identified by comparative metagenomics [PDF]

npj Biofilms and Microbiomes
The vaginal microbiome, a relatively simple, low diversity ecosystem crucial for female health, is often dominated by Lactobacillus spp. Detailed strain-level data, facilitated by shotgun sequencing, can provide a greater understanding of the mechanisms ...
Sai Ravi Chandra Nori, Calum J. Walsh, Fionnuala M. McAuliffe, Rebecca L. Moore, Douwe Van Sinderen, Conor Feehily, Paul D. Cotter   +6 more
doaj   +8 more sources

Lactobacillus crispatus attenuates Escherichia coli-induced inflammation and migration of cervical cancer cells [PDF]

AMB Express
Comprehensive research has indicated that Lactobacillus, serving as the predominant bacterial genus in the female reproductive tract, effectively restrains pathogenic microorganisms and plays a vital role in upholding urogenital health.
Dongli Tian, Lei Deng, Enting Lu, Huayang Li, Fanyi Meng, Xinyang Chen, Yi Zhang, Ye Sun   +7 more
doaj   +2 more sources

Machine learning-based prediction of BV-relevant probiotic functional potential in vaginal-derived Lactobacillus crispatus strains [PDF]

BMC Microbiology
The vaginal microbiota plays a pivotal role in maintaining female reproductive health and homeostasis. However, most currently available Lactobacillus isolates have been developed for the prevention and treatment of intestinal diseases, whereas strain ...
Keyu Quan, Weichi Liu, Hao Jin, Weiwei Hu, Qinggele Borjihan, Qiuhua Bao, Yongfu Chen   +6 more
doaj   +2 more sources

Vaginal microbe-binding antibody interactions with a Lactobacillus crispatus live biotherapeutic following treatment for bacterial vaginosis [PDF]

Microbiology Spectrum
The vaginal application of LACTIN-V, a live biotherapeutic containing Lactobacillus crispatus CTV-05, reduces the recurrence of bacterial vaginosis (BV) and promotes L. crispatus colonization; however, colonization success is variable.
Rachel Liu, Eric Armstrong, Anke Hemmerling, Steve Miller, Sanja Huibner, Laurel Lagenaur, Thomas P. Parks, Craig R. Cohen, Bryan Coburn, Rupert Kaul   +9 more
doaj   +2 more sources

Pilus-mediated co-aggregation with Lactobacillus crispatus increases meningococcal susceptibility to antimicrobial agents by interfering with microcolony formation [PDF]

BMC Microbiology
Background Neisseria meningitidis asymptomatically colonizes the nasopharyngeal mucosa, but occasionally, the bacteria disseminate to cause sepsis and meningitis.
Kenny Lidberg, Sarah Pilheden, Samuddi Nawarathne, Katharina Rauscher, Ann-Beth Jonsson   +4 more
doaj   +2 more sources

'From women for women': A citizen science approach engaging women in the isolation and application of the vaginal health-associated bacterium Lactobacillus crispatus. [PDF]

PLoS ONE
A vaginal microbiome rich in Lactobacillus crispatus is associated with good reproductive and sexual health outcomes. Dysbiosis, indicated by the loss of Lactobacillus crispatus, is a risk factor for urogenital infections, such as the clinical diagnosis ...
Shardelice Illidge, Remco Kort, Rosanne Hertzberger, Dutch crispatus Citizen Science Collective   +3 more
doaj   +2 more sources

Genome-wide analysis of Enterococcus faecalis genes that facilitate interspecies competition with Lactobacillus crispatus [PDF]

Journal of Bacteriology
Enterococci are opportunistic pathogens notorious for causing a variety of infections. While both Enterococcus faecalis and Lactobacillus crispatus are commensal residents of the vaginal tract, the molecular mechanisms that enable E.
Ling Ning Lam, Kathryn E. Savage, Camille N. Shakir, José A. Lemos   +3 more
doaj   +2 more sources

Lactobacillus crispatus-Mediated Gut–Reproductive Tract Axis-Alleviated Microbial Dysbiosis and Oviductal Inflammation in a Laying Hen Model [PDF]

Microorganisms
Oviductal inflammation (OI) significantly reduces the egg production and economic returns in poultry farming. While Lactobacillus crispatus (LAC) is effective against inflammation, its role in treating or preventing oviductal inflammation is understudied.
Shinuo Li, Qingfeng Wang, Jinqiu Mi, Haotian Chen, Tianhao Yuan, Yue Wang, Lihong Zhao, Qiugang Ma, Shimeng Huang   +8 more
doaj   +2 more sources

Modulation of group B Streptococcus infection and vaginal cell inflammatory signaling in vitro by Lactobacillus crispatus-loaded electrospun fibers [PDF]

Infection and Immunity
Vaginal colonization by Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is a major risk factor for ascending infections, preterm birth, and neonatal sepsis.
Nagwa El-Baz, Anthony Kyser, Mohamed Y. Mahmoud, Christopher Z. Farrell, Sierra Ginocchio, Hermann B. Frieboes, Ryan S. Doster   +6 more
doaj   +2 more sources