Results 101 to 110 of about 18,294,799 (361)

Early phase pharmacokinetics but not pharmacodynamics are influenced by propofol infusion rate [PDF]

open access: yes, 2009
Background: Conventional compartmental pharmacokinetic models wrongly assume instantaneous drug mixing in the central compartment, resulting in a flawed prediction of drug disposition for the first minutes, and the flaw affects pharmacodynamic modeling ...
Hagihira, Satoshi   +5 more
core   +2 more sources

An audit of studies registered retrospectively with the Clinical Trials Registry of India: A one year analysis

open access: yesPerspectives in Clinical Research, 2019
Background: The Clinical Trials Registry of India (CTRI) was launched in July 2007 and will enter its tenth year in 2017. While its mission is to encourage prospective trial registration, CTRI does permit retrospective trial registration.
Amit R Birajdar   +5 more
doaj   +1 more source

Estimation of time parameter proportionality ratios in large catchments: Case study of the Modder‐Riet River Catchment, South Africa

open access: yesJournal of Flood Risk Management, 2020
Catchment response time parameters, for example, the time of concentration (TC), lag time (TL), and time to peak (TP) are fundamental to event‐based design flood estimation in ungauged catchments.
Christopher E. Allnutt   +2 more
doaj   +1 more source

On the Time-lag of Tensiometers

open access: yesJournal of Agricultural Meteorology, 1968
Using several tensiometers commereially available in Japan, the author examined the effects of water amount on the time-lag of tensiometer's reading and on the relation between moisture content and tension. The structural character and amount of water which is required in changing a division on the reading are shown in Table 1.The instrument which ...
openaire   +3 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

open access: yesMolecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh   +5 more
wiley   +1 more source

A Robust Continuous Time Fixed Lag Smoother for Nonlinear Uncertain Systems

open access: yes, 2013
This paper presents a robust fixed lag smoother for a class of nonlinear uncertain systems. A unified scheme, which combines a nonlinear robust estimator with a stable fixed lag smoother, is presented to improve the error covariance of the estimation ...
Petersen, Ian R., Rehman, Obaid Ur
core   +1 more source

Retrospective analysis of snake victims in Northern India admitted in a tertiary level institute

open access: yesJournal of Anaesthesiology Clinical Pharmacology, 2012
Context: Snake bites are the common cause of morbidity and mortality in tropical countries. Aims: To analyze the outcome of snake bite victims Settings and Design: Retrospective analysis of data from Intensive care unit, Department of Anesthesiology.
Syed Moied Ahmed   +4 more
doaj   +1 more source

Formative time lags in hydrogen [PDF]

open access: yesJournal of Physics D: Applied Physics, 1968
Formative time lags of the order of 10 ns have been measured at pressures up to 50 torr in experimental tubes having plane-parallel electrodes. The range investigated was 50 < E/p < 500 v cm−1 torr−1. Coaxial cable techniques were used throughout the investigation.
D E Davies, B P Betts
openaire   +2 more sources

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

open access: yesFEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna   +4 more
wiley   +1 more source

Time lag between prompt optical emission and gamma-rays in GRBs

open access: yes, 2006
The prompt optical emission contemporaneous with the $\gamma$-rays from $\gamma$-ray bursts (GRBs) carries important information on the central engine and explosion mechanism. We study the time lag between prompt optical emission and $\gamma$-rays in GRB
Akerlof   +12 more
core   +1 more source

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