Results 71 to 80 of about 1,263,681 (273)
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
One-Cell Doubling Evaluation by Living Arrays of Yeast, ODELAY!
G3: Genes, Genomes, Genetics, 2017 Cell growth is a complex phenotype widely used in systems biology to gauge the impact of genetic and environmental perturbations. Due to the magnitude of genome-wide studies, resolution is often sacrificed in favor of throughput, creating a demand for ...
Thurston Herricks +6 more
doaj +1 more source
Superorbital modulation of X-ray emission from gamma-ray binary LSI +61 303
, 2012 We report the discovery of a systematic constant time lag between the X-ray and radio flares of the gamma-ray binary LSI +61 303, persistent over long, multi-year, time scale.
Chernyakova, M. +5 more
core +1 more source
, 2006 Smoothing is essential to many oceanographic, meteorological and hydrological applications. The interval smoothing problem updates all desired states within a time interval using all available observations.
A Gelb +17 more
core +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Environmental Research LettersNitrogen (N) legacy effects are widely recognized as a primary obstacle to the improvements of water quality following mitigation efforts. The exploration of long-term nutrient trajectories for nitrogen model (ELEMeNT-N) has been applied to estimate ...
Jia Zhou +10 more
doaj +1 more source
The Effect of the Peak Discharges of River Danube on Istanbul Strait (Bosphorus)
International Journal of Environment and Geoinformatics, 2020 The Strait of Istanbul (Bosphorus: SoI) is the meeting point of Black Sea and Marmara Sea. It is under influence of many hydrological, oceanographical and meteorological variables.
Yavuz KARSAVRAN +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Lag effects of vegetation of temperature stress on and its ecological risk assessment
Frontiers in Environmental ScienceExtreme high and low temperatures both exert impacts on terrestrial ecosystems. However, current research still lacks a precise assessment of the risk of vegetation loss under simultaneous consideration of different temperature stresses and lag effects ...
Chenxing Fu +4 more
doaj +1 more source