A total of ten 1-2-year-old rabbits died within 2 weeks at a facility in Ehime prefecture in May 2019. Necropsy revealed liver discoloration and fragility, hemorrhage of some organs and blood coagulation failure. On histopathologic examination, necrotizing hepatitis was a common finding, together with fibrin thrombi in the small vessels and hemorrhage ...
Ayako Miyazaki, Patrick G Corr
exaly +6 more sources
Immune response in the recombinant strain of Lagovirus europaeus GI.1a
Lagovirus europaeus/GI.1 is the virus that causes severe and dangerous rabbit haemorrhagic disease (RHD) in rabbits. Recombination formation in RHD viruses is common. Recombination is thought to play a key role in the evolution of lagoviruses and therefore most likely influences the pathogenicity of L. europaeus/GI strains.
Dominika Bębnowska+3 more
openalex +3 more sources
First recognized as highly pathogenic viruses, hare lagoviruses belonging to genotype GII.1 (EBHSV) infect various Lepus species. Genetically distinct benign lagoviruses (Hare Calicivirus, HaCV) have recently been identified but few data have been available so far on these strains.
Clément Droillard+9 more
openalex +6 more sources
Abstract The Lagovirus genus comprises both pathogenic viruses as European brown hare syndrome virus (EBHSV‐ GII.1) and rabbit hemorrhagic disease viruses (RHDV‐GI.1 and RHDV2‐GI.2), that principally infect European brown hares (Lepus europeaus) and European rabbits (Oryctolagus cuniculus), respectively, causing severe necrotic hepatitis, spleen ...
Patrizia Cavadini+2 more
exaly +2 more sources
Viruses that affect lagomorphs have decades of reported history of spillover events. One of these viruses is the causative agent of the so-called rabbit or 'lagomorph' haemorrhagic disease (e.g. Lagovirus europaeus/GI.1 and L. europaeus/GI.2). In particular, L. europaeus/GI.2 has shown a great capacity to recombine with existing lagoviruses.
Roser Velarde+8 more
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Characterisation of Lagovirus europaeus GI–RHDVs (Rabbit Haemorrhagic Disease Viruses) in Terms of Their Pathogenicity and Immunogenicity [PDF]
Rabbit haemorrhagic disease viruses (RHDV) belong to the family Caliciviridae, genus Lagovirus europaeus, genogroup GI, comprising four genotypes GI.1–GI.4, of which the genotypes GI.1 and GI.2 are pathogenic RHD viruses, while the genotypes GI.3 and GI.4 are non-pathogenic RCV (Rabbit calicivirus) viruses.
Beata Tokarz‐Deptuła+4 more
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Evaluation of autophagic and apoptotic markers during infection with animal virus causing hemorrhagic fever in rabbits [PDF]
IntroductionLagovirus europaeus/GI.1 and GI.2 cause severe Rabbit Haemorrhagic Disease, and immune processes are among the important pathomechanisms of the disease.
Dominika Bębnowska+15 more
doaj +3 more sources
Relationship between Anti‐European Brown Hare Syndrome Serological Titers and Brown Hare (Lepus europaeus Pallas) Densities [PDF]
Thirty‐three protected wild game reproduction areas, located in the province of Florence (Central Italy), were monitored for habitat characteristics and hare census over a period of 2 years. A total of 172 hares was captured, checked for sex, and age, and blood samples were taken.
Gisella Paci+5 more
wiley +4 more sources
Apoptotic Cell Death in an Animal Model of Virus-Induced Acute Liver Failure—Observations during Lagovirus europaeus/GI.2 Infection [PDF]
Lagovirus europaeus/GI.2 causes severe and highly fatal Rabbit Hemorrhagic Disease (RHD). Because of its characteristics, this infection is used as an animal model for acute liver failure (ALF). Apoptosis is one of the key processes underlying ALF and has been described as one of the mechanisms of RHD pathogenesis.
Dominika Bębnowska+5 more
openalex +3 more sources
Apoptotic cell death in an animal model of virus-induced acute liver failure – observations during Lagovirus europaeus/GI.2 infection [PDF]
Abstract Lagovirus europaeus/GI.2 causes severe and highly fatal Rabbit Haemorrhagic Disease. Because of its characteristics, this infection is used as an animal model for acute liver failure (ALF). Apoptosis is one of the key processes underlying ALF and has been described as one of the mechanisms of RHD pathogenesis.
Dominika Bębnowska+4 more
openalex +2 more sources