Results 91 to 100 of about 711 (241)

Nusairis/Arab Alawites Between Change and Taqiyya

open access: yesİnsan & Toplum, 2015
Nusairis/Arab Alawites has existed in our country’s Mediterranean coast for many years with their distinctive social and cultural structure, religious beliefs, and ethnical differences.
Özcan Güngör
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

América Latina: entre pluri-confesionalidad y laicidad = Latin America: between pluri-confessionalism and laicity

open access: yesCivitas - Revista de Ciências Sociais, 2011
In Latin America, as in many countries with a Catholic religious hegemony, the building of a lay (secular) regime required of a militant laicism to generate a space for freedoms, in a context of clash between the principles of political liberalism and ...
Blancarte, Roberto
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

The laicism in the Ilnd Republic. The vi I I about historic layman [PDF]

open access: yes, 2000
This work is focussed to the study of Laicism, an aspect of the teaching policy during the IInd Republic in Spain. Particularly, its devopment in the teachers training is proposed, in spite of the opposition and controversial that this poposal has raised.
Cruz Orozco, José Ignacio
core  

Laicism and Religious Education in Córdoba: Its Normative Framework reviewed from a Human Rights Based-Approach [PDF]

open access: yes, 2023
INTRODUCCIÓN. La cuestión de la enseñanza religiosa en la escolarización común a toda la población constituye una cuestión controversial. La forma federal del Estado argentino constituye una clave para la comprensión del tema en el plano nacional y en el
Ruiz, Guillermo Ramón   +1 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

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