Results 71 to 80 of about 711 (241)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The laicism and problem of laicism in Turkey

open access: yes, 2009
Sosyal Bilimler Enstitüsü, Sosyoloji Bölümü, Sosyoloji Ana Bilim Dalı, Kurumlar Sosyolojisi Bilim DalıFarklı inanç gruplarının hoşgörüye dayalı bir şekilde bir arada yaşamalarını sağlayan laiklik, demokrasiyle birlikte anlamına kavuşan bir kavramdır ...
Sertel, Ergin
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

LAICISM APPLICATIONS IN 1930'SACCORDING TO IZMIR PRESS

open access: yes, 2011
Bu çalışmada öncelikle laiklik olgusunun tanımı, ortaya çıkışı ve tarihsel gelişimi incelenmiştir. 1930 yılı ve sonrasındaki laiklik uygulamaları ise makalenin asıl konusunu oluşturmaktadır.
ERCAN, Sibel
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Aborto e democracia Abortion and democracy

open access: yesRevista Estudos Feministas, 2012
A luta pela legalização do aborto pouco tem avançado no Brasil. O artigo observa a importância política da questão. Por um lado, é um índice da laicidade do Estado, que, por sua vez, é condição necessária para a vigência da democracia.
Luis Felipe Miguel
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Islam y Laicidad

open access: yesRevista Internacional de Pensamiento Político, 2015
El Laicismo en el Islam ha separado a musulmanes sunníes y shíies, a los fundamentalistas de los liberales desde hace más de una centuria, como se ha evidenciado en etiquetas como ladiniya e ilmaniya.
Mustafa Akalay Nasser
doaj   +2 more sources

Can Secularism Hinder Democracy? The Turkish Experiment

open access: yesİnsan & Toplum, 2012
The concept of democracy that has gained importance since the end of the Second World War and the relation between state and religion in Turkey have attracted a considerable degree of interest in various academic circles.
Begüm Burak
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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