Results 41 to 50 of about 242 (212)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Mujeres y sociabilidad laica (1875-1931) / Women and secular sociability (1875-1931)
Asparkía, 2006 RESUMEN Este artículo aborda el desigual protagonismo femenino en ámbitos de cultura laica como los movimientos socialista y anarquista, la masonería o el repubiicanismo, a través del estudio de algunas formas de sociabilidad heterodoxa, en concreto el ...
Mónica Moreno Seco, Mónica Moreno Seco
doaj
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
İnsan & Toplum, 2012 This article aims to reveal the secular contents of Muslim practices in Turkey. Secularism is a concept that originated in the west and it has developed a context within its historical process.
Mustafa Tekin
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Akademik İncelemeler Dergisi, 2014 Laiklik, Türkiye düşünce tarihinde entelektüel tartışmaların ve akademik incelemelerin en yoğunluklu konularından birini, belki ilkini oluşturan ve güncelliğini sürdüren bir alanı ifade etmektedir.
Ahmet Koçal
doaj
Quelle place pour le pluralisme religieux dans le mouvement de protestation algérien de 2019 ?
L’Année du Maghreb, 2019 Since February 22nd, 2019, Algerians of all ages mobilized to reject Abdelaziz Bouteflika’s candidacy for a fifth presidential term, and to call for a radical change in the political regime.
Zohra Aziadé Zemirli
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source