Results 101 to 110 of about 12,144 (303)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
1991 Vol. 48: Towards a committed and responsible laity (SRL18)
, 1991 I/D 48 -- THE GENERALATE TEAM, May 1991 -- Towards a committed and responsible laity (SRL18) -- (pg. 1) -- This I/D is offered as an instrument to help our reflections on the role of Spiritans in the formation of, and cooperation with, laity. It is not
The Generalate Team
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Concept of Laity and Clergy in the Orthodox Church
, 2018 The article describes the terminological issues referring to the concept of laity and clergy on the basis of the Holy Scripture and their use in the early Christian Church.
Kostiuczuk, Jakub
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Training Laity to Minister to Inactive Members in the North Tamil Conference
, 2000 Inactive and uninterested members are common in the Seventh-day Adventist Church in the North Tamil Conference. They are the aching, anxious persons who have great difficulty in living in anxiety-provoking settings.
Masillamony, Paulraj
core +1 more source
Moral Aspects of Laity in the Organization of the Roman and Catholic Church
, 2020 Moral Aspects of Laity in the Organization of the Roman and Catholic ...
Urmanowicz, Walenty, Walenty Urmanowicz
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Role of the Laity in the Process of Autocephaly
, 2018 The fundamental principle of the system of the Orthodox Church is the equality of the laity and the clergy who belong to the mystical body of Christ. The clergy and laity are invariably participating in the deaconia of the Church, in varying degrees and ...
Borkowski, Andrzej
core
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source