Results 111 to 120 of about 12,144 (303)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The Laity: Unutilised Social and Church Potential in Croatia

open access: yes, 2012
U radu se obrađuje problematika uloge i mjesta vjernika laika u hrvatskoj Crkvi u posljednjim dvama desetljećima. Hrvatski vjernik laik prije dvadesetak godina nije jednak današnjemu.
Baloban, Stjepan, Stjepan Baloban
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Catholic Identity and the Laity

open access: yes, 2009
Paul F. Lakeland is a contributing author, Maturity and the Lay Vocation: From Ecclesiology to Ecclesiality p. 241-260. Original essays explore the role of the laity within the Catholic Church and the nature of Catholic identity. –Publisher description.
Muldoon, Tim, Lakeland, Paul F.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

The Laity in Christifideles laici

open access: yes, 1989
The background and main characteristics of the papal letter entitled Christifideles laid are presented. Its conetnts are compared with other church documents in which the subject of the laity is mentioned.
Ema Vesely, Vesely, Ema
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Religious Change and the Laity in England

open access: yes, 2008
This looks at the Reformation in England, and in particular at the destruction and re-erection of altars, and makes the case that the laity were active players in this process, either as advocates or opponents of ...
Fincham, Kenneth, Tyacke, N.R.N.
core  

Home - About - Disclaimer - Privacy