Results 41 to 50 of about 562,892 (309)

Lake Ice Monitoring with Webcams and Crowd-Sourced Images

open access: yes, 2020
Lake ice is a strong climate indicator and has been recognised as part of the Essential Climate Variables (ECV) by the Global Climate Observing System (GCOS).
Baltsavias, Emmanuel   +5 more
core   +1 more source

One-dimensional simulation of lake and ice dynamics during winter

open access: yesJournal of Limnology, 2014
An ice formation model, based on the solution of the heat conduction equation across blue ice, white ice and snow cover, is integrated into the Dynamic Reservoir Simulation Model (DYRESM) to allow for one-dimensional (vertical) winter simulation of lake ...
Ali Oveisy, Leon Boegman
doaj   +1 more source

Diffuse scattering in ice Ih

open access: yes, 2014
Single crystals of ice Ih, extracted from the subglacial Lake Vostok accretion ice layer (3621 m depth) were investigated by means of diffuse x-ray scattering and inelastic x-ray scattering.
Bosak, Alexeï   +5 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Hydrographic measurements in Jökulsárlón lagoon, Iceland [PDF]

open access: yes, 2013
Jökulsárlón lagoon is an enclosed lake bordering the retreating Breidamerkurjökull glacier which flows down from the Vatnajökull ice cap. As the glacier calves most of the ice it releases decays within the lake and the addition of the stored fresh water ...
Björnsson, Helgi   +3 more
core  

Changes in Imja Tsho in the Mount Everest Region of Nepal [PDF]

open access: yes, 2014
Imja Tsho, located in the Sagarmatha ( Everest) National Park of Nepal, is one of the most studied and rapidly growing lakes in the Himalayan range. Compared with previous studies, the results of our sonar bathymetric survey conducted in September of ...
Byers, A. C.   +3 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Continuous Loss of Global Lake Ice Across Two Centuries Revealed by Satellite Observations and Numerical Modeling

open access: yesGeophysical Research Letters, 2022
Lake ice loss has been detected worldwide due to recent climate warming, yet spatially and temporally detailed information on the changes in global ice phenology does not exist.
Xinchi Wang   +10 more
doaj   +1 more source

Controls on rapid supraglacial lake drainage in West Greenland: An Exploratory Data Analysis approach [PDF]

open access: yes, 2018
The controls on rapid surface lake drainage on the Greenland ice sheet (GrIS) remain uncertain, making it challenging to incorporate lake drainage into models of GrIS hydrology, and so to determine the ice-dynamic impact of meltwater reaching the ice ...
Arnold, NS   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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