Results 71 to 80 of about 1,538,149 (347)

Hydrographic measurements in Jökulsárlón lagoon, Iceland [PDF]

, 2013
Jökulsárlón lagoon is an enclosed lake bordering the retreating Breidamerkurjökull glacier which flows down from the Vatnajökull ice cap. As the glacier calves most of the ice it releases decays within the lake and the addition of the stored fresh water ...
Björnsson, Helgi, Brandon, Mark, Hodgkins, Richard, Ólaffson, Jón   +3 more
core  

Changes in Imja Tsho in the Mount Everest Region of Nepal [PDF]

, 2014
Imja Tsho, located in the Sagarmatha ( Everest) National Park of Nepal, is one of the most studied and rapidly growing lakes in the Himalayan range. Compared with previous studies, the results of our sonar bathymetric survey conducted in September of ...
Byers, A. C., McKinney, D. C., Rounce, D. R., Somos-Valenzuela, M. A.   +3 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Subglacial lake drainage detected beneath the Greenland ice sheet [PDF]

, 2015
The contribution of the Greenland ice sheet to sea-level rise has accelerated in recent decades. Subglacial lake drainage events can induce an ice sheet dynamic response—a process that has been observed in Antarctica, but not yet in Greenland, where the ...
A Shepherd, A Shepherd, A Sole, AJ Tedstone, AV Sundal, BE Smith, BR Parizek, C Schoof, DJ Wingham, E Hanna, E Rignot, F Walter, HJ Zwally, I Joughin, I Sasgen, ID Bartholomew, IM Howat, IM Howat, JF Nye, K Steffen, LA Stearns, LC Smith, M McMillan, M Morlighem, M Siegfried, M Tedesco, MJ Hoffman, MR van den Broeke, OV Sergienko, RL Shreve, RM Goldstein, RSW van de Wal, S Palmer, SB Das, SH Mernild, SJ Palmer, T Flament, TL Mote, V Chu, W Abdalati   +39 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Analysis of the Variability and Influencing Factors of Ice Thickness during the Ablation Period in Qinghai Lake Using the GPR Ice Monitoring System

Remote Sensing, 2022
As a reliable indicator of regional climate change, the growth and decline of lake ice thickness affect the regional intra–annual heat and energy balance. In this study, a ground-penetrating radar (GPR) ice monitoring system, located approximately 1.7 km
Qixin Wei, Xiaojun Yao, Hongfang Zhang, Hongyu Duan, Huian Jin, Jie Chen, Juan Cao   +6 more
doaj   +1 more source

Cyclic strengthening of lake ice

Journal of Glaciology, 2020
Further to systematic experiments on the flexural strength of laboratory-grown, fresh water ice loaded cyclically, this paper describes results from new experiments of the same kind on lake ice harvested in Svalbard. The experiments were conducted at −12
A. Murdza, A. Marchenko, E. Schulson, C. Renshaw   +3 more
semanticscholar   +1 more source

Dam type and lake location characterize ice-marginal lake area change in Alaska and NW Canada between 1984 and 2019

The Cryosphere, 2022
. Ice-marginal lakes impact glacier mass balance, water resources, and ecosystem dynamics and can produce catastrophic glacial lake outburst floods (GLOFs) via sudden drainage.
B. Rick, D. McGrath, W. Armstrong, S. McCoy   +3 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source