Results 71 to 80 of about 1,324,260 (297)

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source

Reconstruction of ice-sheet changes in the Antarctic Peninsula since the Last Glacial Maximum [PDF]

, 2014
This paper compiles and reviews marine and terrestrial data constraining the dimensions and configuration of the Antarctic Peninsula Ice Sheet (APIS) from the Last Glacial Maximum (LGM) through deglaciation to the present day.
Glasser, N.F., Davies, Bethan J., Emma P. Hocking (7190990), Larter, Robert D., Larter, R.D., Anderson, J.B., John B. Anderson (7190993), Livingstone, Stephen J., Simms, A.R., Roberts, S.J., Ó Cofaigh, Colm, Domack, E., Evans, J., Hillenbrand, Claus-Dieter, James A. Smith (1496818), Livingstone, Stephen, Michael J. Bentley (7190996), Livingstone, S.J., Dowdeswell, Julian, Anderson, John B., Hocking, Emma, Eugene Domack (6507515), Anderson, John, Canals, M., Canals, Miquel, Roberts, Stephen J., Johnson, J.S., O Cofaigh, C., Stephen J. Roberts (7191008), Hillenbrand, C.D., Larter, Robert, Simms, Alexander, Neil F. Glasser (7191002), Hodgson, Dominic A., Smith, J.A., Julian A. Dowdeswell (7190999), Bentley, Michael J., Colm O Cofaigh (7190984), Jeffrey Evans (1254507), Dowdeswell, Julian A., Hocking, Emma P., Simms, Alexander R., Hillenbrand, Claus Dieter, Hodgson, D.A., Smith, James A., Bentley, M.J., Domack, Eugene, Dowdeswell, J.A., Davies, Bethan, Alexander R. Simms (7191011), Stephen J. Livingstone (3691018), Joanne S. Johnson (7190987), Robert D. Larter (7191005), Johnson, Joanne S., Bentley, Michael, Hodgson, Dominic, Bethan J. Davies (2843855), Glasser, Neil, Miquel Canals (186525), Claus-Dieter Hillenbrand (4276453), Dominic A. Hodgson (2043412), Evans, Jeffrey, Glasser, Neil F., Hillenbrand, C-D., Canals, Miguel, Hocking, E.P., Davies, B.J.   +66 more
core   +1 more source

Long‐Term Lake Ice Evolution in a Large Endorheic Lake Undergoing Accelerated Shrinkage in a Semiarid Region of China

Water Resources Research
Long‐term lake ice evolution under climate change has attracted global attention. However, despite the widespread occurrence of lake shrinkage in endorheic regions worldwide, few studies have explicitly addressed its effects on lake ice regimes.
Tingfeng Wu, Anning Huang, Qi Zhang, Justin Brookes, Wenming Yan, Boqiang Qin, Dequan Han, Xiaofei Hu   +7 more
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Long term trend of chemical oxygen demand in Saroma-ko Lagoon, Japan; possible effects of climatic warming [PDF]

, 2008
A trend of shortening duration of ice coverage has been reported in many rivers, ponds and lakes around the world due to climatic warming. The shortening will have much influence on organic production due to the greater supply of light intensity and ...
Akihiro Shiomoto
core   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Variability of the Lake Onega ice coverage in the period 2000-2018 according to the satellite data

Лëд и снег, 2018
Studying of characteristics of the Lake Onega ice regime and investigating of the climate influence on the formation and destruction of the ice cover requires a continuous chronological series of data on the Lake ice coverage.
V. N. Baklagin
doaj   +1 more source

Lake Ice Investigation at Peters Lake, Alaska [PDF]

Journal of Glaciology, 1963
Abstract In this paper a study of lake ice at Peters Lake with respect to crystallographic nature and impurity in crystal grain boundaries is described. The appearance of the ice structure in 1962 was quite uniform over the whole area of the lake; it showed predominantly horizontal c
Jiro Muguruma, Katsuhiro Kikuchi
openaire   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Lake Diatoms as a Proxy for Holocene Environmental Change, West Greenland [PDF]

, 2013
There is great interest over the Greenland Ice Sheet in terms of future climate change, though there is a lack of understanding of climate change during the Holocene.
BEST, LOUISE,ALICE
core