Results 1 to 10 of about 44,501 (166)
Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration
Molecular Metabolism, 2023 Objective: To date, the only enzyme known to be responsible for the hydrolysis of cholesteryl esters and triacylglycerols in the lysosome at acidic pH is lysosomal acid lipase (LAL).
Dagmar Kratky, Anita Pirchheim
exaly +3 more sources
Secreted enzyme uptake masks the in vivo phenotype of macrophage-specific lysosomal acid lipase deletion [PDF]
Molecular MetabolismBackground and hypothesis: Lysosomal acid lipase (LAL) is so far the only known intracellular enzyme that is capable of hydrolyzing triglycerides and cholesteryl esters at an acidic pH inside the lysosome.
Suravi Mukherjee +8 more
doaj +2 more sources
Lysosomal cholesteryl ester hydrolysis drives white matter repair by reprogramming microglia into a novel reparative state [PDF]
Journal of NeuroinflammationWhite matter repair relies on microglial clearance of cholesterol-rich myelin debris. Microglia have been reported to predominantly depend on de novo sterol synthesis to support this repair process. Lysosomal acid lipase (LAL) is the only known lysosomal
Yu Hu +12 more
doaj +2 more sources
Journal of Lipid Research, 2023 Lysosomal acid lipase (LAL) is the sole lysosomal enzyme responsible for the degradation of cholesteryl esters and triacylglycerols at acidic pH. Impaired LAL activity leads to LAL deficiency (LAL-D), a severe and fatal disease characterized by ectopic ...
Ivan Bradić +6 more
doaj +1 more source
Molecular Genetics and Metabolism Reports, 2022 Background: Lysosomal acid lipase deficiency (LAL-D) is a phenotypic continuum between the severe Wolman disease and the attenuated cholesteryl ester storage disease (CESD).
Xinying Hong +3 more
doaj +1 more source
Language Assessment Literacy of Teachers
Frontiers in Psychology, 2022 Language assessment literacy (LAL) is a significant component of language teachers’ expertise but is also a challenging task for most language teachers. To date, there have been relatively few studies examining the research on teachers’ LAL during these ...
Fanrong Weng, Bin Shen, Bin Shen
doaj +1 more source
TEACHERS LANGUAGE ASSESSMENT LITERACY: A SYSTEMATIC REVIEW
Indonesian EFL Journal, 2022 As an integral part of teaching, assessment is critical since the information from the assessment is essential for many decisions in teaching and learning. Therefore, teachers must hold sufficient knowledge of assessment literacy.
Indah Puspawati
doaj +1 more source
Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver
Cell Death and Disease, 2021 Recent studies demonstrated reduced blood lysosomal acid lipase (LAL) activity in patients with nonalcoholic fatty liver disease (NAFLD). We aimed to verify hepatic LAL protein content and activity in in vitro and in vivo models of fat overload and in ...
Simone Carotti +18 more
doaj +1 more source
Journal of Nanobiotechnology, 2021 Background Photothermal therapy (PTT) is an emerging anti-cancer therapeutic strategy that generates hyperthermia to ablate cancer cells under laser irradiation.
Miyeon Jeon +5 more
doaj +1 more source
Sensitivity of Limulus amebocyte lysate (LAL) to LAL-reactive glucans [PDF]
Journal of Clinical Microbiology, 1991 The sensitivity of Limulus amebocyte lysate (LAL) to LAL-reactive glucans (LRGs) and lipid A was tested by using commercially available and experimentally formulated LAL reagents. The glucans included two kinds of beta-(1,3)-D-glucans, laminarin and curdlan, and cellulosic material, LAL-reactive material (LAL-RM), extracted from a hollow-fiber ...
P F, Roslansky, T J, Novitsky
openaire +2 more sources