Results 81 to 90 of about 28,348 (221)

Survival outcomes and treatment patterns in myelofibrosis in the JAK inhibitor era

British Journal of Haematology, EarlyView.
Summary Data on real‐world survival and treatment patterns in large, unselected myelofibrosis (MF) cohorts remain limited. We analysed 1649 patients with MF diagnosed from 2010 onwards and included in the Spanish Myelofibrosis Registry across 64 centres. Janus kinase (JAK) inhibitors were administered to approximately half of the patients.
Juan‐Carlos Hernández‐Boluda, Eduardo Arellano‐Rodrigo, Manuel Pérez‐Encinas, José‐María Raya, María‐Teresa Gómez‐Casares, Francisca Ferrer‐Marín, Alberto Hernández‐Sánchez, María‐Laura Fox, Anna Angona, Beatriz Cuevas, María‐Isabel Mata‐Vázquez, Rosa Ayala, Natalia de las Heras, Elvira Mora, Valentín García‐Gutiérrez, Alicia Senín, Jasson Villarreal, Blanca Xicoy, Raúl Pérez‐López, María García‐Fortes, Sonia González de Villambrosia, Elena Magro, María‐José Ramírez, Paula Gómez, Angel Ramírez‐Payer, Clara Martínez‐Valverde, Lucía Pérez‐Lamas, Carmen García‐Hernández, Mercedes Gasior, Luis‐Miguel Juárez‐Salcedo, Francisco Ibáñez, María‐Luisa Antelo, Lucía Guerrero, Alberto Alvarez‐Larrán, Arturo Pereira, on behalf of the Spanish MPN Group (GEMFIN)   +35 more
wiley   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

A Real‐World Controlled Multicentre Study Evaluating the Association Between Benralizumab Therapy and Major Outcomes in Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Among patients with severe eosinophilic asthma, benralizumab was associated with greater improvements in asthma outcomes—such as improved asthma control, quality of life and remission rates—compared to biologic‐naïve patients. ABSTRACT Background Real‐world data on benralizumab in patients with severe eosinophilic asthma–while controlling for ...
Dennis Thomas, Vanessa M. McDonald, Gijo Thomas, Joy Lee, Li Ping Chung, Matthew Peters, Shakti D. Shukla, Yuto Hamada, Erin S. Harvey, Michael Fricker, Hayley See, Rejoy Sabin Thomas, Claude S. Farah, Andrew Gillman, Constance H. Katelaris, Gregory P. Katsoulotos, David Langton, Peter G. Middleton, Paul Reynolds, Janet Rimmer, Francis Thien, Stephen Vincent, John W. Upham, Peter G. Gibson   +23 more
wiley   +1 more source

‘Sawa Aqwa’ (Stronger Together): A multi‐site randomized controlled trial of a brief family systemic intervention for adolescent mental health in Lebanon

Journal of Child Psychology and Psychiatry, EarlyView.
Background There are no evaluated family‐based mental health and psychosocial support (MHPSS) interventions for adolescents in Southwest Asia (known as the Middle East), and few whole‐family interventions in low‐ and middle‐income countries, despite consistent evidence for the impact of family support on mental health and well‐being. This study aims to
Tania Bosqui, Felicity L. Brown, Sally Farah, Joseph Elias, Maliki E. Ghossainy, Anas Mayya, Diana Abo Nakkoul, Bryony Walsh, Sarah Chreif, Ahmad Einein, Bassel Meksassi, Roula Abi Saad, Hady Naal, Michael Donnelly, Theresa S. Betancourt, Alan Carr, Eve S. Puffer, Estefania Hanna, Hasan Mansour, Farah Semaan, Rabih El Chammay, Mark J.D. Jordans   +21 more
wiley   +1 more source

Effect of Gender on Lung Function and Patient-Reported Outcomes in Patients with COPD Receiving Nebulized Glycopyrrolate

International Journal of COPD, 2020
Jill A Ohar,1 Ayca Ozol-Godfrey,2 Thomas Goodin,2 Shahin Sanjar2 1Department of Internal Medicine, Wake Forest University, Winston-Salem, NC, USA; 2Sunovion Pharmaceuticals Inc., Marlborough, MA, USACorrespondence: Jill A OharDepartment of Internal ...
Ohar JA, Ozol-Godfrey A, Goodin T, Sanjar S   +3 more
doaj  

PlantCV v4: Image analysis software for high‐throughput plant phenotyping

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract PlantCV is an open‐source Python project aimed at developing tools to address a range of image‐based, plant phenotyping questions. PlantCV has been used for more than 10 years to automate trait collection from image data, and the newest release, PlantCV version 4, continues to lower the barrier to entry for users without substantial coding ...
Haley Schuhl, Keely E. Brown, Hudanyun Sheng, Parag K. Bhatt, Jorge Gutierrez, Dominik Schneider, Anna L. Casto, Lucia Acosta‐Gamboa, Joe G. Ballenger, Fabio Barbero, Jackson Braley, Autumn M. Brown, Leonardo Chavez, Shannon Cunningham, Malinda Dilhara, Adam M. Dimech, Joseph G. Duenwald, Annika Fischer, Jared M. Gordon, Chloe Hendrikse, Gabriela L. Hernandez, John G. Hodge, Martina Huber, Brandon M. Hurr, Sanaz Jarolmasjed, Karina Medina Jimenez, Samuel Kenney, Grant Konkel, Alexander Kutschera, Sunita Lama, Matthew Lohbihler, Argelia Lorence, Collin Luebbert, Nathaniel Ly, Heather K. Manching, Annarita Marrano, Susan Meerdink, Nicholas M. Miklave, Pavan Mudrageda, Katherine M. Murphy, J. David Peery, Ronald Pierik, Seth Polydore, Caleb Robey, Tess Rogers, Tyler J. Schultz, Eliza Seigel, Dhiraj Srivastava, Stephan Summerer, Josh Sumner, Chong Teng, Adriane E. Thompson, Jose C. Tovar, Tim van Daalen, Mark Watson, John J. Wheeler, Mark C. Wilson, Kaitlyn R. Ying, Alina Zare, Yutai Zhou, Malia A. Gehan, Noah Fahlgren   +61 more
wiley   +1 more source

What Distinguishes Very Satisfied From Somewhat Satisfied Financial Advisory Clients

FINANCIAL PLANNING REVIEW, Volume 9, Issue 3, September 2026.
ABSTRACT Using primary data collected in May 2024, this study examines factors associated with very satisfied clients among 639 US investors who use a full‐service financial advisor and have at least $250,000 in investable assets. Within the sample, 68% reported being very satisfied with their advisor, while 32% reported being somewhat satisfied ...
Matthew Sommer, Sonya Lutter
wiley   +1 more source

Long‐Term Prognosis and Immunotranscriptomic Landscape in Esophageal Squamous Cell Carcinoma With Different Pathological Responses to Neoadjuvant Chemoradiotherapy: A Retrospective Cohort Study

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This study comprehensively characterizes the long‐term prognosis and immunotranscriptomic landscape associated with different tumor regression grades (TRGs) in esophageal squamous cell carcinoma (ESCC) following neoadjuvant chemoradiotherapy. By integrating bulk RNA‐seq, single‐cell transcriptomics, and multiplexed immunohistochemistry, we demonstrate ...
Jianye Yuan, Zelin Weng, Xinke Zhang, Fangqi Deng, Zihui Tan, Jian Zhong, Rui Chen, Xiuying Xie, Xiaodan Lin, Ting Lin, Yan Huang, Qianwen Liu, Jing Wen, Jianhua Fu   +13 more
wiley   +1 more source

New pharmacological options in the chronic obstructive pulmonary disease

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2016
Chronic obstructive pulmonary disease is a disseminated process with important clinical and economic implications. A bibliographic review of scientific articles published in PubMed, Scielo and MEDLINE between 2010 and 2015 was carried out concerning the ...
Surama Martínez Chávez, Igber González de la Cruz, Alfredo Enrique Arredondo Bruce   +2 more
doaj  

Comparative functional morphological study of the tarsal joint mobility in artiodactyls and perissodactyls in light of astragalar morphological differences

Journal of Anatomy, Volume 249, Issue 3, Page 587-603, September 2026.
This study investigated how variations in the shape of the astragalus affect tarsal joint behavior, using CT scans. In artiodactyls with a double‐pulley astragalus, the calcaneus shifted plantarly during plantarflexion. This suggests the movement increases hindlimb functional length and contributes to enhanced running speed.
Sei‐ichiro Takeda, Yoichi Masuda, Truong Son Nguyen, Hideki Endo   +3 more
wiley   +1 more source