Results 61 to 70 of about 749,660 (377)

Precision targeting of genetic variations in mixed bacterial cultures using CRISPR-Cas12a-programmed λ phages

Frontiers in Microbiology
The CRISPR-Cas system, an adaptive immune mechanism in prokaryotes against bacteriophages, has been developed into a versatile tool for recognizing and cleaving target nucleic acid sequences.
Chan Kyeong Lee, Ho Joung Lee, Song Hee Jeong, Sang Jun Lee   +3 more
doaj   +1 more source

Nonhuman Primate Induced Pluripotent Stem Cells in Regenerative Medicine

Stem Cells International, 2012
Among the various species from which induced pluripotent stem cells have been derived, nonhuman primates (NHPs) have a unique role as preclinical models.
Yuehong Wu, Anuja Mishra, Zhifang Qiu, Steven Farnsworth, Suzette D. Tardif, Peter J. Hornsby   +5 more
doaj   +1 more source

Estimating present‐day European seasonal mean rainfall by combining historical data and climate model simulations, for risk assessment

Meteorological Applications, 2021
Building risk models for present‐day climate requires an understanding of recent climate trends. To estimate the climate change driven component of recent rainfall trends in Europe, we introduce a novel methodology for combining trend estimates from ...
Stephen Jewson, Francesco Comola, Ben Parkes   +2 more
doaj   +1 more source

Double $\Lambda$ and the $\Lambda-\Lambda$ Interaction

, 1997
The $\Lambda$-$\Lambda$ effective interaction, in the channel $L=S=0$, in the nuclear medium is fitted to the available binding energies, $B_{\Lambda\Lambda}$, of double $\Lambda$ hypernuclei: $^{6}_{\Lambda\Lambda}$He, $^{10}_{\Lambda\Lambda}$Be and $^{13}_{\Lambda\Lambda}$B. The mesonic decay of these hypernuclei is also investigated.
Caro, J., García-Recio, C., Nieves, J. M.   +2 more
openaire   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Morphometry of Superior Sagittal Sinus and Its Clinical Significance

Indian Journal of Neurosurgery
The position of the superior sagittal sinus (SSS) in the midline along the sagittal suture is still a debate among neurosurgeons. The aim of the study is to evaluate the diameter and deviation of the SSS at various landmarks in the midline.
Grace Suganya, Ariharan Krishnaraj, Raveendranath Veeramani, Dinesh Kumar, Nagarajan Krishnan   +4 more
doaj   +1 more source

Simultaneous Analysis of P53 Protein Expression and Cell Proliferation in Irradiated Human Lymphocytes by Flow Cytometry

Dose-Response, 2014
P53 protein has an intrinsic role in modulating the cellular response against DNA radioinduced damages and has been pointed out as an indirect indicator of individual radiosensitivity.
Rafael de Freitas e Silva, Neyliane Frassinetti Gonçalves dos Santos, Valéria Rêgo Alves Pereira, Ademir Amaral   +3 more
doaj   +1 more source

Wild Horse Demography: Implications for Sustainable Management Within Economic Constraints

Human-Wildlife Interactions, 2018
Management of wild horse (Equus ferus caballus ) populations on western U.S. rangelands has been a challenge since horses were given legal protection through the passage of the Wild Free-Roaming Horses and Burros Act (WFRHBA) in 1971.
Robert A. Garrott
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source