Co-Delivery of Sustained Release Chondroitinase ABC-37 With Human iPSC-Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke. [PDF]
Adv Sci (Weinh)A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Letko Khait N +7 more
europepmc +2 more sources
The Journal of Cell Biology, 2004 Laminin-1 is emerging as the key molecule in early embryonic basement membrane assembly. Here we review recent insights into its functions gained from the synergistic application of genetic and structural methods.
Sasaki, T., Fässler, R., Hohenester, E.
openaire +3 more sources
Fluids and Barriers of the CNS, 2022 Background Unlike other proteins that exhibit a diffusion pattern after intracerebral injection, laminin displays a vascular pattern. It remains unclear if this unique vascular pattern is caused by laminin-receptor interaction or laminin self-assembly ...
Jingsong Ruan +3 more
doaj +1 more source
Improvement of human embryonic stem cell-derived retinal pigment epithelium cell adhesion, maturation, and function through coating with truncated recombinant human vitronectin [PDF]
International Journal of Ophthalmology, 2021 AIM: To explore an xeno-free and defined coating substrate suitable for the culture of H9 human embryonic stem cell-derived retinal pigment epithelial (hES-RPE) cells in vitro, and compare the behaviors and functions of hES-RPE cells on two culture ...
Xin-Yue Zhu +7 more
doaj +1 more source
Laminin is the ECM niche for trophoblast stem cells
Life Science Alliance, 2020 Laminin functions as an ECM niche factor for trophoblast stem cells and secures trophoblast stem cell expansion through its interactions with integrin. The niche is a specialized microenvironment for tissue stem cells in vivo. It has long been emphasized
Daiji Kiyozumi +4 more
doaj +1 more source
Laminin concentration in ascites of patients with hepatic cirrhosis and peritoneal carcinomatosis
Brazilian Journal of Medical and Biological Research, 2005 Laminin levels in ascitic fluid have been proposed as a marker for neoplastic ascites. We compared the concentration of laminin in serum and in ascitic fluid from patients with hepatic cirrhosis and peritoneal carcinomatosis and assessed the diagnostic ...
R.M. Catarino +3 more
doaj +1 more source
Endogenous laminin is required for human airway smooth muscle cell maturation
Respiratory Research, 2006 Background Airway smooth muscle (ASM) contraction underlies acute bronchospasm in asthma. ASM cells can switch between a synthetic-proliferative phenotype and a contractile phenotype.
Tran Thai +4 more
doaj +1 more source
The association of laminin levels with insulin resistance and non-alcoholic hepatosteatosis
Diabetology & Metabolic Syndrome, 2021 Background Laminin, one of the largest glycoproteins of the basement membrane, is an important component of the extracellular matrix. Functions of the basement membrane include regulation of cell signaling behaviors and structural support.
Özgür Altun +8 more
doaj +1 more source
Serum level of laminin in rats fed with a high-fat diet with sulodexide administration
Бюллетень сибирской медицины, 2022 Background. Increased consumption of animal fat with food contributes to the accumulation of lipids both in the blood and in individual cell structures.
O. G. Gileva +2 more
doaj +1 more source
Cumulative prognostic power of laminin genes in colorectal cancer
BMC Medical Genomics, 2018 Background Laminins are a major family of extracellular matrix proteins and the main component of basement membranes. Laminins are involved in many if not all stages of cancer progression, and expression of laminin genes has prognostic value in various ...
Vladimir V. Galatenko +4 more
doaj +1 more source