Results 21 to 30 of about 108,751 (260)

Human laminin-111 and laminin-211 protein therapy prevents muscle disease progression in an immunodeficient mouse model of LAMA2-CMD

Skeletal Muscle, 2020
Background Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result in progressive muscle wasting and inflammation leading to delayed milestones, and ...
Pamela Barraza-Flores, Hailey J. Hermann, Christina R. Bates, Tyler G. Allen, Timothy T. Grunert, Dean J. Burkin   +5 more
doaj   +1 more source

CNS Neurons Deposit Laminin α5 to Stabilize Synapses

Cell Reports, 2017
Summary: Synapses in the developing brain are structurally dynamic but become stable by early adulthood. We demonstrate here that an α5-subunit-containing laminin stabilizes synapses during this developmental transition.
Mitchell H. Omar, Meghan Kerrisk Campbell, Xiao Xiao, Qiaonan Zhong, William J. Brunken, Jeffrey H. Miner, Charles A. Greer, Anthony J. Koleske   +7 more
doaj   +1 more source

Laminin 511-E8, an autoantigen in IgG4-related cholangitis, contributes to cholangiocyte protection

JHEP Reports
Background & Aims: IgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease. Anti-laminin 511-E8 autoantibodies have been identified in its pancreatic manifestation.
David C. Trampert, Remco Kersten, Dagmar Tolenaars, Aldo Jongejan, Stan F.J. van de Graaf, Ulrich Beuers   +5 more
doaj   +1 more source

Current approaches to the diagnosis of autoimmune bullous dermatoses

Vestnik Dermatologii i Venerologii, 2021
A modern review of highly effective methods for the diagnosis of autoimmune bullous dermatoses are presented. The specificity of the production of autoantibodies underlying bullous dermatoses are described.
Marianna B. Drozhdina, Varvara A. Bobro, Yuliana A. Sennikova   +2 more
doaj   +1 more source

Anti-laminin-1 Autoantibodies, Pregnancy Loss and Endometriosis

Clinical and Developmental Immunology, 2004
Laminin-1 is a major component and multifunctional glycoprotein of basement membranes that consists of three different subunits, α1, β1 and γ1 chains. It is the earliest synthesized network-forming protein during embryogenesis and
Junko Inagaki, Akane Kondo, Luis R. Lopez, Yehuda Shoenfeld, Eiji Matsuura   +4 more
doaj   +1 more source

Specific decellularized extracellular matrix promotes the plasticity of human ocular surface epithelial cells

Frontiers in Medicine, 2022
The ocular surface is composed of two phenotypically and functionally different epithelial cell types: corneal and the conjunctival epithelium. Upon injury or disease, ocular surface homeostasis is impaired resulting in migration of conjunctival ...
Tiago Ramos, Tiago Ramos, Mohit Parekh, Paula Meleady, Finbarr O’Sullivan, Rosalind M. K. Stewart, Rosalind M. K. Stewart, Rosalind M. K. Stewart, Stephen B. Kaye, Stephen B. Kaye, Kevin Hamill, Sajjad Ahmad, Sajjad Ahmad, Sajjad Ahmad, Sajjad Ahmad   +14 more
doaj   +1 more source

Overexpression of LAMC2 predicts poor prognosis in colorectal cancer patients and promotes cancer cell proliferation, migration, and invasion

Tumor Biology, 2017
Laminin γ2 (LAMC2) has been reported to be involved in the development and progression of a variety of tumors. However, its function in human colorectal cancer is unclear. Our study aimed to investigate the role of laminin γ2 in colorectal cancer.
Dandan Huang, Changzheng Du, Dengbo Ji, Jianzhong Xi, Jin Gu   +4 more
doaj   +1 more source

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration

Cell Reports, 2017
Endothelial basement membranes constitute barriers to extravasating leukocytes during inflammation, a process where laminin isoforms define sites of leukocyte exit; however, how this occurs is poorly understood.
Jian Song, Xueli Zhang, Konrad Buscher, Ying Wang, Huiyu Wang, Jacopo Di Russo, Lixia Li, Stefan Lütke-Enking, Alexander Zarbock, Anika Stadtmann, Paul Striewski, Benedikt Wirth, Ivan Kuzmanov, Heinz Wiendl, Dörte Schulte, Dietmar Vestweber, Lydia Sorokin   +16 more
doaj   +1 more source

Impairment Mechanisms and Intervention Approaches for Aged Human Neuromuscular Junctions

Frontiers in Molecular Neuroscience, 2020
The neuromuscular junction (NMJ) is a chemical synapse formed between a presynaptic motor neuron and a postsynaptic muscle cell. NMJs in most vertebrate species share many essential features; however, some differences distinguish human NMJs from others ...
Yomna Badawi, Hiroshi Nishimune, Hiroshi Nishimune   +2 more
doaj   +1 more source

Nerve Fiber Immunohistochemical Panel Discriminates between Nerve Sheath and Perivascular Wall Tumors

Veterinary Sciences, 2022
Benign and malignant nerve sheath tumors (NST) pose a major challenge in routine diagnostic anatomic pathology because of shared histomorphological features with other soft-tissue tumors (STT).
Sílvia Sisó, Paola Marco-Salazar, Paola Roccabianca, Giancarlo Avallone, Robert J. Higgins, Verena K. Affolter   +5 more
doaj   +1 more source