Results 91 to 100 of about 125,741 (149)

Gemcitabine-induced β4 integrin drives cancer progression and gemcitabine resistance in pancreatic cancer

Journal of Experimental & Clinical Cancer Research
Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by high mortality and the frequent emergence of chemoresistance, particularly to gemcitabine (GEM).
Yoshinobu Kariya, Haruto Suzuki, Yukiko Kariya, Michiru Nishita   +3 more
doaj   +1 more source

THE ROLE OF THE LAMININ-332-ACTIN-CHOLESTEROL AXIS IN SKIN CONDITIONS WITH ALTERED LIPID PROFILES [PDF]

The skin serves a critical barrier function, which is compromised in several conditions, leading to increased water loss and dry skin. Recent studies indicate that laminin-332, a basement membrane extracellular matrix protein, contributes to barrier ...
Parzymies, P
core   +3 more sources

Laminin-defined mechanical status modulates retinal pigment epithelium phagocytosis

EMBO Reports
Epithelial cells exhibit strong interconnections that are crucial for tissue mechanical properties. In homeostasis, these properties, termed mechanical homeostasis, depend on the balance between intercellular tension and extracellular matrix (ECM ...
Aleksandra N Kozyrina, Teodora Piskova, Francesca Semeraro, Iris C Doolaar, Taspia Prapty, Tamás Haraszti, Maxime Hubert, Reinhard Windoffer, Rudolf E Leube, Ana-Sunčana Smith, Jacopo Di Russo   +10 more
doaj   +1 more source

Efficient Dual Cas9 Nickase Correction of a Prevalent Pathogenic LAMB3 Variant for Junctional Epidermolysis Bullosa

JID Innovations
Gene editing facilitated by homology-directed repair represents a promising strategy for precisely correcting pathogenic variants underlying monogenic disorders, including the life-threatening skin blistering condition junctional epidermolysis bullosa ...
Alex du Rand, John Hunt, Daniel Verdon, Ben Buttle, P. Rod Dunbar, Diana Purvis, Vaughan Feisst, Hilary Sheppard   +7 more
doaj   +1 more source

Brunsting-Perry Pemphigoid of the Scalp with Antibodies against Laminin 332 [PDF]

, 2011
S. Zgažarová, Zgazarova, S., A. Niedermeier, M. Hertl, Hertl, M., H. Jedlickova, Jedlickova, H., Niedermeier, A.   +7 more
core   +1 more source

Laminin 332 expression levels predict clinical outcomes and chemotherapy response in patients with pancreatic adenocarcinoma. [PDF]

Front Cell Dev Biol, 2023
Sari B, Gulbey O, Hamill KJ.
europepmc   +1 more source

effects of tailored laminin‐332 α3 conjugated scaffolds enhances wound healing: A histomorphometric analysis

, 2013
Surface modification techniques have been used to develop biomimetic scaffolds by incorporating cell adhesion peptides. In our previous work, we have shown the tethering of laminin-332 α3 chain to type I collagen scaffold using microbial transglutaminase
Martin Griffin, Griffin, Martin, Pandit, Abhay, Tiong, William H C, Harshad Navsaria, William H. C. Tiong, Damodaran, Gopinath, Collighan, Russell, Abhay Pandit, Navsaria, Harshad, Gopinath Damodaran, Russell Collighan   +11 more
core   +1 more source

Laminin-332 γ2 Monomeric Chain Promotes Adhesion and Migration of Hepatocellular Carcinoma Cells. [PDF]

Cancers (Basel), 2023
Scialpi R, Arrè V, Giannelli G, Dituri F.   +3 more
europepmc   +1 more source

Regulated laminin-332 expression in human islets of Langerhans.

, 2009
International audienceLaminin-332 (LN-332) is a basement membrane component known to exert a beneficial effect on rat pancreatic beta cells in vitro. In this work, we analyzed the expression of LN-332 in human islets, its expression after inflammatory ...
Armanet, Mathieu Pierre Jean, Morel, Philippe, Berney, Thierry, Parnaud, Géraldine, Bosco, Domenico, Sinigaglia, Corinne, Armanet, Mathieu, Wojtusciszyn, Anne, Rousselle, Patricia   +8 more
core   +1 more source

Weekly Intraperitoneal Injection of Tamoxifen in an Inducible In Vivo Model of Junctional Epidermolysis Bullosa Generates Early and Advanced Disease Phenotypes

JID Innovations
Junctional epidermolysis bullosa caused by loss-of-function variants in genes encoding the skin basement membrane proteins laminin 332, type XVII collagen, or integrin α6β4 affects patients from birth with severe blistering, eventually leading to ...
Eleri Mai Jones, Priya Garcha, Monique Aumailley, Edel Anne O’Toole, Emanuel Rognoni, Matthew Caley   +5 more
doaj   +1 more source