Results 91 to 100 of about 11,677 (291)

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

A novel “chassis” PSC line for precise safe harbor site integration via selection-aided RMCE

Stem Cell Research
We describe here a human pluripotent stem cell line (hPSC) designed to serve as an acceptor (a “chassis” cell line) for the recombination-mediated cassette exchange (RMCE)-mediated precise insertion of DNA fragments into a safe harbor locus.
Merve Ay, Desi Veleva, Mohammad M. Chowdhury, Andrew B.J. Prowse, Dmitry A. Ovchinnikov   +4 more
doaj   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

Criteria for lunar site selection [PDF]

, 1970
Lunar landing site selection for comprehensive lunar ...
Binder, A. B., Roberts, D. L.
core   +1 more source

Rosetta Lander Philae – Landing Performance and Touchdown Safety Assessment [PDF]

, 2016
This paper describes the simulation and analysis work on Rosetta lander Philae’s touchdown dynamics which was done to support its landing site selection process.
Roll, R., Biele, J., Ulamec, S., Jurado, E., Witte, L.   +4 more
core   +1 more source

Edge computing business model and key solutions for its landing and deployment

Dianxin kexue, 2020
Edge computing is an innovation of network architecture and business model for operators.5G edge computing node is composed of 5G UPF and edge computing platform.It can be deployed at different levels of the network based on the demand for bandwidth ...
Yuan ZHAO, Bing XIN, Hongyuan MA, Lifeng CHEN   +3 more
doaj   +2 more sources

Vertiport Location Selection and Optimization for Urban Air Mobility in Complex Urban Scenes

Aerospace
Vertiports, as dedicated facilities for electric vertical takeoff and landing (eVTOL) aircraft, are essential to ensure the efficiency and sustainability of Urban Air Mobility (UAM).
Yannan Lu, Weili Zeng, Wenbin Wei, Weiwei Wu, Hao Jiang   +4 more
doaj   +1 more source

Dynamically Modified Flexible Zn Powder Anodes with Stable Performance at High Rate and High Zn Utilization

Advanced Science, EarlyView.
A dynamically shape‐variant liquid metal‐based network is integrated into Zn powder electrode, where intrinsic fluidity and structural adaptability of the liquid metal‐based network enable effective mitigation of dendritic growth, alleviation of stress accumulation, and prevention of Zn loss during Zn plating‐stripping processes.
Yuxuan Wang, Chenhao Li, Wenbo Zhao, Yong Gao, Yiwei Liu, Yuhao Li, Yu Zhang, Yuhan Yao, Abdelnaby M. Elshahawy, Cao Guan   +9 more
wiley   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Sample Science Input to Landing Site Selection for Mars 2020: An In-Situ Exploration and Sample Caching Rover [PDF]

, 2015
One of the Mars 2020 Rover mission’s main objectives is to collect samples of martian material and seal them in individual tubes for possible return by a later mission[1].
Farley, K., Hays, L. E., Beaty, D. W., Williford, K.   +3 more
core