Results 131 to 140 of about 162,701 (257)

Association between hypnotic medication use and in-hospital falls among older adults: A multicenter landmark analysis. [PDF]

PLoS One
Nishino T, Kubota Y, Miyagi Y, Tanabe N, Yamaguchi F, Ito H, Soh S, Yano A, Mizuno M, Kim C, Ishii Y, Kondo Y, Asai K.   +12 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

A deep learning framework for the localization of landmarks on the lateral semi circular canals. [PDF]

PLoS One
Wei Z, Wijewickrema S, Copson B, Gerard JM, O'Leary S.   +4 more
europepmc   +1 more source

Stability of PEA2PbBr4 Thin‐Film Photodetectors under Thermal and Moisture Stress

Advanced Electronic Materials, EarlyView.
This study investigates the environmental durability of 2D perovskite photodetectors under extreme heat and humidity. While pristine films degrade in harsh environmental conditions, adding a halogen‐bonding agent significantly improves stability. This passivated device maintains stable performance in conditions mimicking space and solar applications ...
Sara Cepić, Andrea Ciavatti, Enrico Gianfranco Campari, Beatrice Fraboni   +3 more
wiley   +1 more source

On the Importance of a Clear Definition of Time Horizon for Time-to-Event Dynamic Predictions: A Systematic Review and a Concrete Illustration in Kidney Transplantation. [PDF]

Clin Epidemiol
Chabeau L, Bonnemains V, Rinder P, Giral M, Desmée S, Dantan E.   +5 more
europepmc   +1 more source

Essential Updates 2024–2025: Surgical Strategy for Esophageal Cancer Toward a New Paradigm in the Era of Immunotherapy and Personalization

Annals of Gastroenterological Surgery, EarlyView.
This review summarizes key advances from 2024 to 2025 that are reshaping esophageal cancer surgery toward a strategy‐oriented, personalized paradigm through the integration of immunotherapy, population aging, and intelligent technologies. Adjuvant nivolumab after neoadjuvant chemoradiotherapy remains the only perioperative approach with durable benefit,
Shuichiro Oya, Koichi Yagi, Yoshifumi Baba   +2 more
wiley   +1 more source

Association of a dual-index phenotype and early ICU reassessment with 28-day in-hospital mortality in cardiogenic shock: a single-center observational cohort study. [PDF]

Front Cardiovasc Med
Luo R, Zeng Z, Li J, Yao H, Xu W, Lan X.
europepmc   +1 more source

Clinical Significance of PD‐L1 and HLA Expression in Esophageal Squamous Cell Carcinoma in Response to Immunotherapy

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated immune‐related biomarkers in esophageal squamous cell carcinoma treated with immune checkpoint inhibitors after postoperative recurrence. PD‐L1 expression in tumor‐associated macrophages and tumor cells, together with HLA class I downregulation and HLA‐DR expression, were associated with favorable responses to immunotherapy.
Kosuke Kanemitsu, Yoshiyuki Tagayasu, Yoshihiro Komohara, Cheng Pan, Rin Yamada, Yukio Fujiwara, Kazuto Harada, Keisuke Kosumi, Yoshifumi Baba, Masaaki Iwatsuki   +9 more
wiley   +1 more source

A Video-Based Measurement Framework for Chewing-Event Detection Using 3D Facial Landmark Dynamics and sEMG-Based Reference Annotation. [PDF]

Sensors (Basel)
Giulietti N, Massotti C, Giberti H.
europepmc   +1 more source