Results 151 to 160 of about 283,448 (300)

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Predicting the Reactivity of Acyclic Silylenes and Germylenes in Hydrogen Activation Using Machine Learning

Advanced Science, EarlyView.
Statistical models for the prediction of the energy profile of H2 activation by silylenes and germylenes were developed. A simple model based on increments of the elements in α‐position enabled robust energy prediction, extrapolation to new structures, and transferability to new tetrylenes and substrates.
Michelle Kleinhaus, Henning Remm, Prasenjit Palui, Alexander Linke, Viktoria H. Gessner   +4 more
wiley   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Decoding Interfacial Polymerization Through Steady Amine Delivery and Real‐Time QCM‐D Monitoring

Advanced Science, EarlyView.
We combine steady amine delivery with in situ quartz crystal microbalance with dissipation to track interfacial polymerization in real time. The platform resolves three kinetic regimes: pre‐gelation oligomerization, post‐gelation aggregation and network growth, and diffusion‐limited film evolution.
Yu Fang, Yu‐Ren Xue, Cheng‐Ye Zhu, Hong‐Qing Liang, Zhi‐Kang Xu   +4 more
wiley   +1 more source

Freestanding PZT Films for Integrated Wearable Sensing and Intelligent Acoustic Recognition

Advanced Science, EarlyView.
A freestanding epitaxial PZT/LaNiO3/Pt heterostructure is achieved via water‐assisted delamination from mica, effectively eliminating substrate‐induced clamping and releasing intrinsic ferroelectricity. The released film exhibits substantially enhanced remanent polarization and piezoelectric response, delivering excellent mechanical flexibility and ...
Hailong Pan, Zhichao Xu, Rongxiao Liu, Jianmei Pei, Changhong Yang, Shifeng Huang, Michael Wübbenhorst   +6 more
wiley   +1 more source

Dynamic risk assessment by landmark modeling of the restricted residual mean survival time. [PDF]

Lifetime Data Anal
Zhang Y, Schaubel DE.
europepmc   +1 more source

Low Threshold Vertical Cavity Surface Emitting Lasers Based on CsPbI3 Thin Films

Advanced Science, EarlyView.
The first vertical‐cavity surface‐emitting laser (VCSEL) based on CsPbI3 thin films is fabricated by planar hot pressing. By optimizing the cavity design through optical gain assessment and rigorous coupled‐wave analysis, the VCSEL achieved an exceptionally low lasing threshold of 2.8 µJ cm−2.
Naho Kurahashi, Maximilian Schiffer, Cedric Kreusel, Christian Tückmantel, Ahmed Kadid, Habib Ur Rehman, Florian Gaschler, René Anfang, Christopher Knoth, Maximilian Buchmüller, Patrick Görrn, Thomas Riedl   +11 more
wiley   +1 more source

Molecular Rectification: Mechanisms, Modulation Strategies, and Device Realization

Advanced Science, EarlyView.
This review focuses on molecular rectification, from its fundamental mechanisms and modulation strategies to device realization. It summarizes the theoretical framework, modulation strategies, fabrication techniques, characterization methods, and modeling and simulation of molecular rectifiers, while discussing challenges and future directions for ...
Junnan Guo, Shufan Song, Wenhui Fang, Jifeng Tang, Wenhao Li, Weikang Wu, Shishen Yan, Hui Li, Lishu Zhang   +8 more
wiley   +1 more source

Serial H&E Pathology Reveals Progression‐Associated Nuclear Size Drift as a Longitudinal Digital Readout of Bladder Cancer Evolution

Advanced Science, EarlyView.
Routine serial H&E specimens from bladder cancer are converted into paired T0/T1 digital pathology readouts of tumor evolution. Progression is associated with longitudinal nuclear drift, with nuclear size‐related changes most evident in the independent confirmation cohort, alongside a broader spatial burden of increased nuclear area and biological ...
Xing Liu, Zhen‐Duo Shi, Gong‐Cheng Wang, Jian‐Ming Wang, Ying Liu, Yi Gong, Xuan Lin, Di Wu, Shi‐Chao Zhuo, Han Han, Yi‐Bing Shi, Fan‐Lai Meng, Yu Zhang, Zhi‐Gang Jia, Cong‐Hui Han   +14 more
wiley   +1 more source