Results 141 to 150 of about 3,501,652 (356)
Molecular Oncology, EarlyView.This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain +3 more
wiley +1 more source
The diversity of evolutionary dynamics on epistatic versus non-epistatic fitness landscapes [PDF]
arXiv, 2014 The class of epistatic fitness landscapes is much more diverse than the class of non-epistatic landscapes, and so it stands to reason that there exist dynamical phenomena that can only be realized in the presence of epistasis. Here, we compare evolutionary dynamics on all finite epistatic landscapes versus all finite non-epistatic landscapes, under ...
arxiv
Искусство Евразии, 2017 В начале XX века виды искусства идут по пути их наибольшего сближения. Особенно тесно начинают взаимодействовать литература и изобразительное искусство. Но формы и степень этих взаимодействий различны.
Филиппова, О.Н.
doaj +1 more source
Olympic Landscapes: A Global Event on a Local Landscape [PDF]
, 2012 Recently, cities around the globe have become involved in a competition for obtaining the title of the most “powerful” city in the world. Hosting mega-events, like the Olympics allow for these cities to restructure the entire floor plan of their ...
Silva, Krista
core +2 more sources
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Epistasis and the structure of fitness landscapes: are experimental fitness landscapes compatible with Fisher's Geometric model? [PDF]
arXiv, 2015 The fitness landscape defines the relationship between genotypes and fitness in a given environment, and underlies fundamental quantities such as the distribution of selection coefficient, or the magnitude and type of epistasis. A better understanding of variation of landscape structure across species and environments is thus necessary to understand ...
arxiv
Путь художественных исканий. Андрей Осипович Никулин
Искусство Евразии, 2016 Статья посвящена анализу творчества и уникальности пути художественных исканий в начале ХХ века талантливого русского живописца А.О. Никулина (1878-1945), внесшего значительный вклад в развитие русской изобразительной культуры, но в силу сложившихся ...
Бабина, О.А.
doaj +1 more source
Shifting Core and Slipping Foundation: An Uncertain Future of Landscape Architecture in European Universities [PDF]
, 2010 Faced with the dual and often conflicting necessity to be scientific and design practices the discipline of landscape architecture today is challenged to re-examine its core and intellectual foundation.
Koh, J.
core +1 more source
MIF as an oncogenic driver of low‐heterogeneity melanomas
Molecular Oncology, EarlyView.Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran +4 more
wiley +1 more source
Predicting Landscapes from Environmental Conditions Using Generative Networks [PDF]
arXiv, 2019 Landscapes are meaningful ecological units that strongly depend on the environmental conditions. Such dependencies between landscapes and the environment have been noted since the beginning of Earth sciences and cast into conceptual models describing the interdependencies of climate, geology, vegetation and geomorphology.
arxiv