Results 121 to 130 of about 1,334,232 (314)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Projets de Paysage, 2016 For the most part, Photographic Observatories of the Landscape are confronted with limiting factors when it comes to facilitating the sharing of documents, the sustainability of archiving and the reliability of metadata as well as the capacity to use it.
Laurence Le Dû-Blayo, Caroline Guittet
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Cahiers des Amériques LatinesThe aim of this article is to know how the ritual practice of Apantla builds the “pueblo” of Santa Catarina del Monte. I use the sociology of collectives, the anthropology of ritual, and cultural geography to address the processual idea of making a town ...
Patricia Montiel Rogel
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Landscape aesthetics: towards a better understanding of rural landscape preferences [PDF]
The central aim of this study was to gain greater insights into the factors that affect individuals’ preferences for a variety of landscape settings. To achieve this aim, this paper derived dependent variables (based on a factor analysis of respondents ...
Howley, Peter
core +1 more source
Landscape science: a Russian geographical tradition [PDF]
, 2007 The Russian geographical tradition of landscape science (landshaftovedenie) is analyzed with particular reference to its initiator, Lev Semenovich Berg (1876-1950). The differences between prevailing Russian and Western concepts of landscape in geography
Oldfield, Jonathan; id_orcid +3 more
core +1 more source
Projets de Paysage, 2016 In the context of the landscape’s extreme prominence as a discourse, composition, and image, initiatives for the photographic observation of the landscape are developing in France.
Frédérique Mocquet
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Benefit estimates for landscape improvements: sequential Bayesian design and respondents’ rationality in a choice experiment [PDF]
, 2006 A multi-attribute, stated-preference approach is used to value low and high impact actions on four major landscape components addressed by the Rural Environment Protection Scheme in Ireland.
Campbell, Danny +6 more
core +1 more source