Results 121 to 130 of about 1,326,395 (314)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Urban landscape ecology and its evaluation : a review [PDF]

open access: yes, 2009
Urban landscapes exhibit combinations of environmental features that are rarely encountered in non-urban settings resulting in habitat types, habitat associations and vegetation communities not found elsewhere.
Young, Christopher   +7 more
core  

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Living Wandle Landscape Partnership: Final Evaluation & Completion Report [PDF]

open access: yes, 2018
Living Wandle (LW) is the National Lottery's first urban Landscape Partnership (LP) Scheme. Focused on the catchment of the River Wandle and covering parts of the London Boroughs of Croydon, Merton, Sutton and Wandsworth, its distinctive features ...
Anteric, M., Clarke, R.
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Practicing Landscape Field Guide No. 2: Landscapes of Energy and Extraction: Landscape as Archive

open access: yes
Practicing Landscape Field Guides are a series of publications that Reading Landscape has developed from a series of online seminars run during academic year 2021-22, entitled Practicing Landscape: Landscapes of Energy and Extraction.
Hale, Alex   +3 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Transformations agroécologiques dans une ville-patrimoine : la durabilité de l’agriculture urbaine au prisme du paysage

open access: yesTerritoire en Mouvement
Given the difficulty of grasping the complexity and diversity of urban agriculture, this article focuses on two professional urban farms in fairly close geographical proximity. It proposes to explore the landscape fabric of these installations, combining
Sophie Bonin
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

The 'Landscape Character Turn': An Examination of Experience in the UK and Taiwan [PDF]

open access: yes, 2012
Landscape policy in the UK has a tradition of conserving natural beauty within designated areas. As a result of both the progressive development of landscape analysis techniques, of which the most recent is the use of Landscape Character Assessment (LCA),
CHENG, HSIAO-YUN
core  

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