Results 111 to 120 of about 1,334,232 (314)

A Changing Landscape

open access: yesPLoS Biology, 2003
Open-access publication is inarguably valuable to science and to the public, yet skepticism about the long-term sustainability of open-access publications persists (see Nature, October 9, and Science, October 24). While some fear the effects of the open-access model—which shifts revenue streams from subscription fees to publication fees—on scientific ...
Helen Doyle, Andy Gass, Debra Lappin
openaire   +4 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Society, culture and people in landscape research [PDF]

open access: yes, 2007
Landscape is a concept which straddles the natural and social sciences, bringing together a variety of physical and cultural elements. This study aims to assess the relative level of importance that physical and cultural landscape elements are ...
25 Years of Landscape Ecology: Scientific Principles in Practice   +3 more
core  

Une marginalité spatiale comme clé de lecture des territoires

open access: yesTerritoire en Mouvement, 2011
Until the end of the XIX century and the phylloxeric episode, vine was one of the principal resources in Haute-Saône. According to agricultural statistics, since the nineteen seventies this culture has officially disappeared from most of the villages of ...
Sylvain Estager
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

“The Landscape of wheat - A landscape of power” pp: 66-70 [PDF]

open access: yes, 2016
Portugal in the end of the 19 th century was characterized by a huge economic and political instability. This situation led to the publication of the Hunger Law (1899), which is identified as the critical breaking point since it imposed a political ...
Simões, Paula, Carapinha, Auroa
core  

ECONOMIC AND FINANCIAL ASPECTS OF ACTIVITY IN SC "AGRO ANCA" SRL, RO.IORII DE VEDE, COUNTY TELEORMAN (2011-2012) [PDF]

open access: yesScientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2014
The unit was established in 2008, with the object of activity "permanent cultivation of plants" - NACE Code 011 principal activity "Growing of cereals (except rice), leguminous crops and oil seeds plant".
Radu Lucian PÂNZARU   +1 more
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

On a landscape approach to design and eco-poetic approach to Landscape [PDF]

open access: yes, 2008
For Landscape Architecture to become an academic discipline it must present its own coherent theory and methodology for the planning, designing and management of (built) landscapes.
Koh, J.
core  

Shifting shores: Transformative learning with the city

open access: yesJournal of Social Science Education
Highlights: – Post-human methodologies support geographical experimentation in social science education – Walking with a virtual (Deleuze) landscape manifests the materiality of the city – Diverse temporal and spatial rhythms reveal the subject as
William Smolander, Raine Aiava
doaj   +1 more source

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