Results 111 to 120 of about 1,326,395 (314)

L’Observatoire photographique national du paysage : transformations d’un modèle et hypothèses renouvelées de paysage

open access: yesProjets de Paysage, 2016
In the context of the landscape’s extreme prominence as a discourse, composition, and image, initiatives for the photographic observation of the landscape are developing in France.
Frédérique Mocquet
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Monitoring landscape‐level distribution and migration Phenology of Raptors using a volunteer camera‐trap network

open access: yesWildlife Society Bulletin, 2015
Conservation of animal migratory movements is among the most important issues in wildlife management. To address this need for landscape‐scale monitoring of raptor populations, we developed a novel, baited photographic observation network termed the ...
David S. Jachowski   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Iconographical landscape warfare

open access: yes, 2020
© 2019, © 2019 Landscape Research Group Ltd. Iconographical landscape warfare is one example of conflict that refers to a broad spectrum of encounters between opposing social groups who share a common reading of cultural landscapes. This 'warfare' ranges
Yoon, Hong-Key
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

The University of Minnesota Preservation Plan, 1998

open access: yes, 1998
Landscape Research. (1998). The University of Minnesota Preservation Plan, 1998.
Landscape Research
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Landscape architect (Ohio Board of Landscape Architect Examiners)

open access: yes, 1998
Spring 1998-Summer/Fall 1999.; Title from caption.; Harvested from the web on 3/17 ...

core   +1 more source

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