Results 91 to 100 of about 1,326,395 (314)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Musealized landscapes and petrified landscapes
Polish Journal of Landscape Studies, 2020 The text aims to reflect upon the notion of landscape in the context of exhibitions; more precisely, it aims to do so in relation to the musealization of archaeological heritage and presentation of archaeology. The last 30 years of museum transformations, referred to as “the age of museums,” and the digital shift in museology have had a significant ...
openaire +2 more sources
PLoS Biology, 2003 Open-access publication is inarguably valuable to science and to the public, yet skepticism about the long-term sustainability of open-access publications persists (see Nature, October 9, and Science, October 24). While some fear the effects of the open-access model—which shifts revenue streams from subscription fees to publication fees—on scientific ...
Helen Doyle, Andy Gass, Debra Lappin
openaire +4 more sources
Society, culture and people in landscape research [PDF]
, 2007 Landscape is a concept which straddles the natural and social sciences, bringing together a variety of physical and cultural elements. This study aims to assess the relative level of importance that physical and cultural landscape elements are ...
25 Years of Landscape Ecology: Scientific Principles in Practice +3 more
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Une marginalité spatiale comme clé de lecture des territoires
Territoire en Mouvement, 2011 Until the end of the XIX century and the phylloxeric episode, vine was one of the principal resources in Haute-Saône. According to agricultural statistics, since the nineteen seventies this culture has officially disappeared from most of the villages of ...
Sylvain Estager
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
3D modelling in landscape practice in New Zealand
, 2013 The profession of landscape architecture has undergone significant change over the last 40 years, both internationally and locally. The New Zealand Institute of Landscape Architects (NZLIA) is keen to establish a profile of landscape architecture in New
Barthelmeh, M
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Landscape values: Place and praxis
, 2018 Proceedings of the international Landscape Values: Place and Praxis conference hosted by the Centre for Landscape Studies (NUI Galway) on behalf of UNISCAPE.
Newman, Conor +3 more
core +1 more source
ECONOMIC AND FINANCIAL ASPECTS OF ACTIVITY IN SC "AGRO ANCA" SRL, RO.IORII DE VEDE, COUNTY TELEORMAN (2011-2012) [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2014 The unit was established in 2008, with the object of activity "permanent cultivation of plants" - NACE Code 011 principal activity "Growing of cereals (except rice), leguminous crops and oil seeds plant".
Radu Lucian PÂNZARU +1 more
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source