Results 81 to 90 of about 1,326,395 (314)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Landscape as Archive [PDF]

Landscape as Archive is a collaborative creative research publication which explores a particular hyperlocality on the Altyre Estate, a Bronze Age cist site.
Hale, Alex, Wall, Gina
core  

Landscape Infrastructure in Sydney: exemplars of landscape synergies and capacity by design [PDF]

, 2016
The landscape architecture undergraduate programme at the University of Technology Sydney introduced landscape infrastructure as a subject into its curriculum in 2016.
Kilbane, S, Kilbane, Simon, Josephine Neldner, Simon Kilbane, Kilbane, SJ, Neldner, Josephine, Neldner, J   +6 more
core   +1 more source

Les moulins du Clos du Cotentin : contribution à l’étude d’un facteur et indicateur de l’évolution du territoire et de ses contingences naturelles et anthropiques

In Situ, 2012
The mills which are to be seen scattered over the old maps of the Cotentin Peninsula bear witness to forgotten customs. They left their mark on local landscapes even after they had been abandoned and the roads leading to them were no longer frequented ...
Benoît Canu
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Paysage, architecture rurale, territoire : de la prise de conscience patrimoniale à la protection

In Situ, 2012
For a long time, heritage protection in France meant the protection of historic monuments, exceptional buildings “of national interest for history or for art”, as the law of 1887 formulated it.
Arlette Auduc
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Addressing the interplay of poverty and the ecology of landscapes: a Grand Challenge Topic for landscape ecologists?

, 2010
We argue for the landscape ecology community to adopt the study of poverty and the ecology of landscapes as a Grand Challenge Topic. We present five areas of possible research foci that we believe that landscape ecologists can join with other social and ...
Pijanowski, Bryan C., Bartsch, Annett, Wimberly, Michael C., Wimberly, Michael, Iverson, Louis R., Drew, Ashton, Bulley, Henry, Bulley, Henry N. N., Pijanowski, Bryan, Drew, C. Ashton, Iverson, Louis, Rhemtulla, Jeanine M., Peng, Jian   +12 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Design thinking in landscape architecture

, 2015
Landscape architects are well placed to bring their creativity and their creative thinking skills to contribute to the development of solutions for many of the world's environmental and community-based problems.
Barthelmeh, MR
core