Results 141 to 150 of about 1,334,232 (314)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Living Wandle Landscape Partnership: Final Evaluation & Completion Report [PDF]
, 2018 Living Wandle (LW) is the National Lottery's first urban Landscape Partnership (LP) Scheme. Focused on the catchment of the River Wandle and covering parts of the London Boroughs of Croydon, Merton, Sutton and Wandsworth, its distinctive features ...
Anteric, M., Clarke, R.
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Landscape Assessment via Regression Analysis [PDF]
This paper presents a methodology for assessing the visual quality of agricultural landscapes through direct and indirect techniques of landscape valuation. The first technique enables us to rank agricultural landscapes on the basis of a survey of public
Ruiz, Pedro +5 more
core +1 more source
University of Illinois at Urbana-Champaign Department of Landscape Architecture graduate program : school evaluation report, 1980-81 [PDF]
, 1980 Made available in DSpace on 2011-11-08T16:28:15Z (GMT). No. of bitstreams: 2 universityofillini00univ.pdf: 8006228 bytes, checksum: 8ccc5fee911ba9b1ae70763c8781a907 (MD5) license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5 ...
Riley, Robert B. +1 more
core
Territoire en MouvementGiven the difficulty of grasping the complexity and diversity of urban agriculture, this article focuses on two professional urban farms in fairly close geographical proximity. It proposes to explore the landscape fabric of these installations, combining
Sophie Bonin
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
The 'Landscape Character Turn': An Examination of Experience in the UK and Taiwan [PDF]
, 2012 Landscape policy in the UK has a tradition of conserving natural beauty within designated areas. As a result of both the progressive development of landscape analysis techniques, of which the most recent is the use of Landscape Character Assessment (LCA),
CHENG, HSIAO-YUN
core
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source