Results 41 to 50 of about 3,501,652 (356)

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

The KPZ equation and the directed landscape [PDF]

arXiv, 2023
This paper proves the convergence of the narrow wedge solutions of the KPZ equation to the Airy sheet and the directed landscape. This is the first convergence result to the Airy sheet and the directed landscape established for a positive temperature model.
arxiv  

Man versus machine: cost and carbon emission savings of 4G-connected Artificial Intelligence technology for classifying species in camera trap images

Scientific Reports
Timely and accurate detection and identification of species are crucial for monitoring wildlife for conservation and management. Technological advances, including connectivity of camera traps to mobile phone networks and artificial intelligence (AI ...
James Smith, Ashleigh Wycherley, Josh Mulvaney, Nathan Lennane, Emily Reynolds, Cheryl-Ann Monks, Tom Evans, Trish Mooney, Bronwyn Fancourt   +8 more
doaj   +1 more source

Landscape Study in Wireless and Mobile Learning in the post-16 sector [PDF]

, 2005
In the post-16 sector (further and higher education, and adult and community learning) there is a need to understand how wireless and mobile technologies can contribute to improving the student experience of learning, and help institutions fulfil their ...
Evans, Diane, Kukulska-Hulme, Agnes, Traxler, John   +2 more
core  

The chromatin accessibility landscape of primary human cancers

Science, 2018
Cancer chromatin accessibility landscape The Cancer Genome Atlas (TCGA) provides a high-quality resource of molecular data on a large variety of human cancers. Corces et al.
M. Corces, Jeffrey M. Granja, Shadi Shams, Bryan H. Louie, J. Seoane, Wanding Zhou, T. Silva, C. Groeneveld, Christopher K. Wong, S. Cho, Ansuman T. Satpathy, Maxwell R Mumbach, K. Hoadley, A. G. Robertson, Nathan C. Sheffield, Ina Felau, Mauro A. A. Castro, B. Berman, L. Staudt, J. Zenklusen, P. Laird, C. Curtis, W. Greenleaf, Howard Y. Chang   +23 more
semanticscholar   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1962-1973, December 2022., 2022
Abstract Objectives Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis.
Adrià Tort‐Merino, Neus Falgàs, Isabel E. Allen, Mircea Balasa, Jaume Olives, José Contador, Magdalena Castellví, Jordi Juncà‐Parella, Núria Guillén, Sergi Borrego‐Écija, Bea Bosch, Guadalupe Fernández‐Villullas, Oscar Ramos‐Campoy, Anna Antonell, Lorena Rami, Raquel Sánchez‐Valle, Albert Lladó   +16 more
wiley   +1 more source

Conversation Piece: Landscape Now

British Art Studies, 2018
We are in the midst of a new era of place perception in Britain. Questions of what landscapes mean to us, who sees them, and what they are for are all being debated now with an intensity perhaps unmatched since the first great age of domestic tourism ...
Alexandra Harris, Susan Owens, Fiona Stafford, Rachel Hewitt, Felicity Myrone, Anna Pavord, Emily Hayes, Barney Norris, Caroline Garrett, Mark Bills   +9 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Localization on the Landscape and Eternal Inflation [PDF]

, 2014
We investigate the validity of the assertion that eternal inflation populates the landscape of string theory. We verify that bubble solutions do not satisfy the Klein Gordon equation for the landscape potential. Solutions to the landscape potential within the formalism of quantum cosmology are Anderson localized wavefunctions.
arxiv   +1 more source