Results 41 to 50 of about 682,231 (268)
Landscape of Serotypes Pneumococcus Isolate with Pneumococcal Meningitis in the Russian Federation
Эпидемиология и вакцинопрофилактика, 2015 Invasive pneumococcal serotypes landscape in various Russian regions studied. The study showed dominance (in decreasing order of importance) serogroups/serotypes 3, 6, 19, 4, 23, 18, 14, 15, 7, 11 and 9, which accounted for 88% of all identified ...
G. V. Beloshitsky +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Belgeo, 2004 In the federal state Belgium, landscape research evolved from regional geographical monographs to more applied research that focuses upon the specific problems in each of the regions.
Marc Antrop +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Exploration touristique des rivières de France, entre description et mythification (1904-1924)
Belgeo, 2013 Travel stories constitute a literature that reveals the development of nautical tourism. The rediscovery of French rivers, carried out by well-off city dwellers, is based on myths about the return to nature and the personification of the elements. It’s a
Eric Levet-Labry
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Landscape Painting in Russian Fine Art after Levitan. The Ivanovo Region in Painting: A Century’s Experience [PDF]
Художественная культураThe article discusses the issues of regional art schools and the place of landscape in the modern classification of genres in art based on the material of the intermuseum exhibition project The Ivanovo Region in Painting.
Sergeeva Tatiana D.
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source