Results 91 to 100 of about 3,064,611 (299)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Deconstruction in landscape architecture

open access: yes, 2009
The possibilities for a rigorous deconstruction in landscape architecture are explored, based largely upon the theoretical work of Jacques Derrida, and the architectural work of Bernard Tschumi.
Snead, John Peyton
core  

Genome-wide transcriptional and metabolic responses of Eschscholzia californica to salt stress

open access: yesBMC Plant Biology
Eschscholzia californica, as an abiotic stress-tolerant ornamental plant, has long been studied for phylogenetic analysis and biosynthesis of benzylisoquinoline alkaloids. However, little is known about its environmental adaptation mechanisms.
Zhuo Huang   +8 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

On a landscape approach to design and eco-poetic approach to Landscape [PDF]

open access: yes, 2008
For Landscape Architecture to become an academic discipline it must present its own coherent theory and methodology for the planning, designing and management of (built) landscapes.
Koh, J.
core  

What part of the brain is involved in graphic design thinking in landscape architecture? [PDF]

open access: yesPLoS One, 2021
Tsai YP   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

A genome-wide association study reveals molecular mechanism underlying powdery mildew resistance in cucumber

open access: yesGenome Biology
Background Powdery mildew is a disease with one of the most substantial impacts on cucumber production globally. The most efficient approach for controlling powdery mildew is the development of genetic resistance; however, few genes associated with ...
Xuewen Xu   +8 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

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