Results 131 to 140 of about 177,351 (312)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Notes at the Edge of Landscape

This thesis examines landscape in the course of an itinerancy and positions the road as its constant figurative as well as allegorical component. The examination is applied on a cohesive body of original photographic work selected from two published ...
Petridis, Paris
core  

Landscape Ecological Risk and Drivers of Land-Use Transition under the Perspective of Differences in Topographic Gradient

Human activities have caused different degrees of land-use change on different topographic gradients, with impacts on the landscape and ecosystem. Effectively preventing and addressing ecological risk (ER) and achieving harmonious coexistence between ...
Xuebin Zhang, Hucheng Du, Haoyuan Feng, Jiale Yu, Litang Yao, Xuehong Li, Yanni Liu   +6 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Land use changes, landscape ecology and their socioeconomic driving forces in the Spanish Mediterranean coast (the Maresme County, 1850-2005)

We use a set of landscape metrics to study the long-term environmental transformation of a typical coastal Mediterranean area from 1850 to 2005. Our figures show a dramatic environmental deterioration between 1950 and 2005.
Lluis Parcerisas, Francesc Coll, Joan Marull, Enric Tello, Joan Pino, Corina Basnou   +5 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Liquid Landscape: Southam, Constable, and the Art of the Pond

, 2018
Water, in its various forms—from rivers to clouds, and amphibious sites, from marshes to meadows—has long been an integral, perhaps characteristic presence in the landscape arts in Britain.
Stephen Daniels
core   +1 more source

Evaluation of Cultivated Land Fragmentation and Analysis of Driving Factors in the Major Grain-Producing Areas of the Middle and Lower Yangtze River Basin

Land
Cultivated land fragmentation has become a critical constraint on regional agricultural sustainable development. Revealing its spatial patterns and driving mechanisms is of great significance for optimizing the utilization and management of cultivated ...
Jiangtao Gou, Cuicui Jiao
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source