Results 141 to 150 of about 177,351 (312)

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Landscape structure and the long-term decline of cyclic grey-sided voles in Fennoscandia

, 2010
Changes in forest landscape structure have been suggested as a likely contributing factor behind the long-term decline in the numbers of cyclic grey-sided voles (Clethrionomys rufocanus) in northern Fennoscandian lowland regions in contrast to mountain ...
Ecke, Frauke, Ecke, Frauke,, Christensen, Pernilla, Sandström, Per, Sandström, Per,, Sveriges lantbruksuniversitet., Nilsson, Mats,, Hörnfeldt, Birger,, Christensen, Pernilla,, Nilsson, Mats, Rentz, Ralf, Rentz, Ralf,   +11 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Reconciling natural habitat size loss and quality enhancement: the dual effects of urbanization in China’s Loess Plateau

Environmental Research Letters
Amid accelerating urbanization and severe biodiversity loss in global drylands, reconciling urbanization with habitat conservation is crucial for sustainable development.
Siya Li, Qiulei Ji, Wei Liang, Tingting Wang, Wenbin Liu, Hong Wang, Yao Feng, Fen Gou, Zhenguo Wang, Fubao Sun   +9 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A methodology for the development of a sustainability index for construction works in Spain

, 2010
The present paper tries to describe in a systematic way the process followed to develop a methodology to obtain a Sustainable Index for Construction Works in Spain. Given the complexity of the task at hand, and having into account that this is the first
Antuña Rozado, Carmen, García Navarro, Justo   +1 more
core   +1 more source

The absence of absence: a (geographical hi)story of the landscape of Blackpool [PDF]

, 2008
Throughout the past decade contemporary human geography has seen a decisive move away from the structuralist analysis of the New Cultural era, to a more fluid, deconstructed and poststructuralist approach, perhaps best encapsulated within the ...
Shires, Kate
core  

Effects of landscape pattern change on waterbird diversity in Xianghai Nature Reserve

Open Geosciences
In order to study the change of landscape pattern and its impact on waterbird diversity in Xianghai Nature Reserve, this article analyzes the changing landscape pattern of the reserve from 2014 to 2017 at the landscape and type level. Pearson correlation
Zhao Yuelan, Liu Jiping, Li Huifen, Zhao Dandan   +3 more
doaj   +1 more source

Temporal and Spatial Changes of Soil Erosion and Its Response to Landscape Pattern in Dabie Mountains of Western Anhui in Recent 30 Years

Shuitu Baochi Xuebao
[Objective] The Dabie Mountain area in western Anhui Province is an important ecological transition area between the Yangtze River Basin and the Huaihe River Basin in Anhui Province.
TIAN Changyuan, ZHANG Hongli, WANG Junhong, LI Jianing, ZHANG Yi, ZHA Tonggang   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source