Results 111 to 120 of about 5,508,906 (294)

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

open access: yesMolecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński   +12 more
wiley   +1 more source

The Green Building Index (GBI): an innovation in landscape architecture [PDF]

open access: yes, 2011
This paper presents a review of the Green Building Index as a new innovation in landscape architecture scope of works. The Green Building Index (GBI) is a green rating system introduced by the Pertubuhan Arkitek Malaysia (PAM) to evaluate the performance
Mohd. Hussain, Mohd. Ramzi   +2 more
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

From urban beautification to a holistic approach: the discourses of ‘landscape’ in the Arab Middle East [PDF]

open access: yes, 2016
: The English word and Western idea of landscape was introduced during the colonial restructuring of Arab cities in the early decades of the twentieth century.
Makhzoumi, Jala M.
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Analysis of Spatial Distribution and Impact Factors on Rural Settlement Based on Village Region—A Case Study of Balong Village in Lengshui Town, Shizhu County, Chongqing City

open access: yesShuitu baochi yanjiu, 2014
The spatial distribution adjustment and optimization of rural residential area,as one of the important contents of the new round of Overall Planning of Land Use, play an important part on the coordination on balance urban and rural development.
MIN Jie
doaj  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Analysis on the Characteristics of the Landscape Pattern of Land Use in Tongnan County

open access: yesShuitu baochi yanjiu, 2005
Based on the information source of landscape map of 2000,the landscape indexes including characteristics of patch number,patch size,diversity index,evenness index and fragment index are calculated,analyzed and compared in order to disclose the spatial ...
HE Bing-hui~1, XU Xia~1, GU Shi-xian~2
doaj  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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