Results 71 to 80 of about 5,176,691 (243)

Ecological Risk in the Mountainous Metropolis of Chongqing: Historical Assessment and Flows of SSPs-RCPs Scenarios

Shuitu Baochi Xuebao
[Objective] Chongqing is a mega-metropolis located in the southwestern hilly region. The rising population and extensive economic development have led to rapid urban landscape ascent and expansion, resulting in a dual urban-rural and 3D spatial structure
WEI Mengyu, BIAN Hongyan, GAO Jie, ZHANG Lujin, JIA Runxi, LI Haolin, WANG Linyong   +6 more
doaj   +1 more source

Spatial Pattern Consistency among Different Remote-Sensing Land Cover Datasets: A Case Study in Northern Laos

ISPRS International Journal of Geo-Information, 2019
Comparisons of the accuracy and consistency of different remote-sensing land cover datasets are important for the rational application of multi-source land cover datasets to regional development, or to studies of global or local environmental change ...
Junmei Kang, Lichun Sui, Xiaomei Yang, Zhihua Wang, Chong Huang, Jun Wang   +5 more
doaj   +1 more source

The Landscape Resilience Index: a flexible tool for integrated landscape management

Frontiers in Sustainable Food Systems
Globally, landscapes are subject to intensifying and interacting environmental pressures, making landscape resilience increasingly important for sustaining ecosystem services, livelihoods, and long-term development. Integrated landscape management offers a promising approach to strengthening resilience, yet many existing monitoring frameworks are not ...
W. Ovenden, E. Durrant, S. Ovenden, E. Ishengoma, S. Davis, M. A. Borges, M. Matediane, M. Esmael, C. Metta, A. Mhagama, A. Al Dwairi   +10 more
openaire   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

A GIS-Based Study on Optimized Spatial Distribution of Rural Settlements in Mayang County

Shuitu baochi yanjiu, 2010
Optimum Spatial Distribution of Rural Settlements is an important way to solve the current distribution of scattered and inefficient use of rural settlements.In this paper,Mayang county is taken as an example,by means of GIS spatial analysis and ...
TAN Xue-lan, DUAN Jian-nan, BAO Chun-hong, ZHU Hong-mei   +3 more
doaj  

Pattern change and ecological risk analysis of Shilin World Geopark landscape

Frontiers in Ecology and Evolution
This study considered Shilin World Geopark as the research object and constructed a landscape ecological risk assessment model based on the landscape pattern index by using remote sensing image data during five periods between 2000 and 2020. In addition,
Yiqi Shi, Hongxia Gao, Shucheng Tan, Shucheng Tan, Hongfu Qin, Zhuang Tian, Jingxian Meng, Xin Zheng   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

PM_2.5 Sink-Source Dichotomy in Urban Clusters: Land Cover Efficiency Gradients and Socio-Meteorological Interactions

Atmosphere
Urban clusters face escalating atmospheric challenges, with elevated PM2.5 concentrations representing a critical environmental constraint. This study investigates spatiotemporal evolution mechanisms of PM2.5 within China’s Taiyuan-Yuci-Xinzhou (TYX ...
Jian Yao, Yaolong Zhao
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source