Results 61 to 70 of about 5,327,669 (304)

Pattern change and ecological risk analysis of Shilin World Geopark landscape

Frontiers in Ecology and Evolution
This study considered Shilin World Geopark as the research object and constructed a landscape ecological risk assessment model based on the landscape pattern index by using remote sensing image data during five periods between 2000 and 2020. In addition,
Yiqi Shi, Hongxia Gao, Shucheng Tan, Shucheng Tan, Hongfu Qin, Zhuang Tian, Jingxian Meng, Xin Zheng   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Response of the Desertification Landscape Patterns to Spatial–Temporal Changes of Land Use: A Case Study of Salaxi in South China Karst

Land, 2023
Land use change and karst desertification (KD) are interdependent. It is crucial to investigate the relationship between the KD landscape and spatial–temporal changes in land use for effective and sustainable KD management practices in karst plateau ...
Tian Shu, Kangning Xiong, Ning Zhang
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

PM_2.5 Sink-Source Dichotomy in Urban Clusters: Land Cover Efficiency Gradients and Socio-Meteorological Interactions

Atmosphere
Urban clusters face escalating atmospheric challenges, with elevated PM2.5 concentrations representing a critical environmental constraint. This study investigates spatiotemporal evolution mechanisms of PM2.5 within China’s Taiyuan-Yuci-Xinzhou (TYX ...
Jian Yao, Yaolong Zhao
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analysis of the Evolution of Land Use Carbon Metabolism Patterns and the Response to Urban Form Changes in Haikou, China

Land
It is increasingly recognized that urban planning is essential in promoting low-carbon urban development, and the research on urban carbon metabolism patterns informs the theoretical support for carbon neutrality through urban structural optimization. To
Zuoyuan Zhang, Hui Fu, Xiaocui Feng, Shuling Li   +3 more
doaj   +1 more source

Unraveling the clinical significance and prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response index, and delta neutrophil index: An extensive literature review

Turkish Journal of Emergency Medicine
In the field of critical care medicine, substantial research efforts have focused on identifying high-risk patient groups. This research has led to the development of diverse diagnostic tools, ranging from basic biomarkers to complex indexes and ...
Mehmet Muzaffer Islam, M. O. Satıcı, S. Eroğlu   +2 more
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source