Results 81 to 90 of about 177,351 (312)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Construction and Optimization of Wetland Landscape Ecological Network in Dongying City, China
, 2022 Rapid urbanization has led to deteriorated wetland water quality, reduced biodiversity, and fragmented wetland landscapes, which seriously threaten the sustainable development of regional ecology.
Linzhe Yang +5 more
core +1 more source
LandIt is increasingly recognized that urban planning is essential in promoting low-carbon urban development, and the research on urban carbon metabolism patterns informs the theoretical support for carbon neutrality through urban structural optimization. To
Zuoyuan Zhang +3 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Additive energy functions have predictable landscape topologies
, 2022 Recent work (J. Chem. Phys. 154, 114114) has demonstrated that sublevelset persistent homology provides a compact representation of the complex features of an energy landscape in $3N$-dimensions.
Aurora, Clark +3 more
core +1 more source
ISPRS International Journal of Geo-Information, 2019 Comparisons of the accuracy and consistency of different remote-sensing land cover datasets are important for the rational application of multi-source land cover datasets to regional development, or to studies of global or local environmental change ...
Junmei Kang +5 more
doaj +1 more source
Indexing the vulnerability of biotopes to landscape changes
Ecological Indicators, 2019 Abstract Biodiversity loss is one of the great challenges of our times, and it is primarily driven by losses of natural and semi-natural areas. To avoid further biodiversity losses, landscape planning and ecosystem management could benefit from a condensed measure that tracks regional and cumulative ecological degradation from past and ongoing ...
openaire +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Landscape metrics as a tool for evaluating scenarios for flood prevention and nature conservation
, 2011 Within the framework of the project "Flood Prevention and Nature Conservation in the Weisseritz area" ("HochNatur"), a method including landscape metrics was developed and applied to assess and to compare different land use scenarios with regard to flood
Hermann Heilmeier +4 more
core +1 more source
A Study on Application of Landscape Diagnosis Index and Landscape Formation Plan of Rural Villages
Journal of Korean Society of Rural Planning, 2013 In this study, it propose what the landscape elements is to be improved urgently and how to improve landscape by reflecting the rural village characteristics away from the spatial integrated landscape planning. The study area for landscape research is selected as the 9 rural villages in Chungcheongbuk-do, and research is done by using village unit ...
Hee-Jung Song +3 more
openaire +2 more sources