Results 141 to 150 of about 99,404 (300)

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Landscape metrics used to quantify spatial pattern.

open access: yes, 2014
Landscape metrics used to quantify spatial pattern.
Yanyan Xu (571830)   +5 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Urban landscape ecology and its evaluation : a review [PDF]

open access: yes, 2009
Urban landscapes exhibit combinations of environmental features that are rarely encountered in non-urban settings resulting in habitat types, habitat associations and vegetation communities not found elsewhere.
Young, Christopher   +7 more
core  

Example data frame of landscape-level metrics.

open access: yes, 2019
Example data frame of landscape-level metrics.
Martí Bosch (8087852)
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

The 'Landscape Character Turn': An Examination of Experience in the UK and Taiwan [PDF]

open access: yes, 2012
Landscape policy in the UK has a tradition of conserving natural beauty within designated areas. As a result of both the progressive development of landscape analysis techniques, of which the most recent is the use of Landscape Character Assessment (LCA),
CHENG, HSIAO-YUN
core  

The response of the water cycle to landscape configuration and composition in two Chilean basins

open access: yesEnvironmental and Sustainability Indicators
Land use/cover change (LUCC) and landscape patterns have an important influence on the hydrological cycle. However, it is still unknown how hydrological processes and streamflow respond to changes in landscape configuration and composition in ...
Marieta Hernández-Sosa   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

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