Results 121 to 130 of about 99,404 (300)

Spatiotemporal analysis of Indian megacities

open access: yes, 2008
Urbanization is arguably the most dramatic form of highly irreversible land transformation. While urbanization is a worldwide phenomenon, it is exceptionally dynamic in India, where unprecedented urban growth rates have occurred over the last 30 years ...
Taubenböck, Hannes   +5 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Metrics Toolkit: A Tool For Navigating The Research Metrics Landscape

open access: yes, 2018
The Metrics Toolkit is an open access resource aimed at helping researchers and evaluators understand and responsibly use research metrics, including bibliometrics and altmetrics. The Toolkit provides evidence-based information about research metrics across disciplines, including how each metric is calculated, where it can be found, and how it should ...
Champieux, Robin   +2 more
openaire   +2 more sources

An Assessment of Leporid Research and Landscape Ecology Metrics in a European Landscape [PDF]

open access: yesJournal of Landscape Ecology, 2013
Abstract Leporids play a dynamic role in the ecosystem and assessments must be undertaken in order to improve research efforts and methods. Landscape ecology metrics are used to quantify components of leporid habitat such as vegetation structure, vegetation cover, habitat type, and fragmentation; however, the degree to which the metrics are ...
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Analysis of urban sprawl at mega city Cairo, Egypt using multisensoral remote sensing data, landscape metrics and gradient analysis

open access: yes, 2009
This paper is intended to highlight the capabilities of synergistic usage of remote sensing, landscape metrics and gradient analysis. We aim to improve the understanding of spatial characteristics and effects of urbanization on city level ...
Taubenböck, Hannes   +4 more
core  

Relationship Between Aggregation Index and Change in the Values of Some Landscape Metrics as a Function of Cell Neighborhood Choice

open access: yesISPRS International Journal of Geo-Information
Landscape metrics are one of the main tools for studying changes in the landscape and the ecological structure of the territory. However, the calculation of some metrics yields significantly different values depending on the configuration of the “Cell ...
Paolo Zatelli   +2 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

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