Results 111 to 120 of about 99,404 (300)
LandQuantifying landscape features and linking them to ecological processes is a key goal of landscape ecology. Urbanization, socio-economic growth, political influences, and morphology have extended built-up and urban regions from the core to the boundaries.
Diksha +6 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Using landscape metrics to analyse urban spatial patterns in the Metropolitan area of Granada
Anales de Geografía de la Universidad Complutense, 2010 Landscape metrics have been widely used to perform analyses of landscape structure, function and change. Within the last years, these metrics have been recently used to analyse urban landscapes.
Francisco Aguilera Benavente
doaj
Metrics Toolkit: an online evidence-based resource for navigating the research metrics landscape
Journal of the Medical Library Association, 2018 While research metrics may seem well established in the scholarly landscape, it can be challenging to understand how they should be used and how they are calculated.
Robin Champieux +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Assessing the environmental destruction in forest ecosystems using landscape metrics and spatial analysis. [PDF]
Sci Rep, 2023 Mansori M +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Application of urban growth boundary delineation based on a neural network approach and landscape metrics for Khulna City, Bangladesh. [PDF]
Heliyon, 2023 Bakshi A, Esraz-Ul-Zannat M.
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source