Results 51 to 60 of about 338,455 (295)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
INVESTIGATING MANGROVE FRAGMENTATION CHANGES USING LANDSCAPE METRICS [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019 Generally, investigation of long-term mangroves fragmentation changes can be used as an important tool in assessing sensitivity and vulnerability of these ecosystems to the multiple environmental hazards.
M. Baharlouii +2 more
doaj +1 more source
Comparison of selected landscape ecological forest metrics in two different landscape types [PDF]
, 2008 By analysing changes in landscape structure we can trace the influence they have on the evaluation of the diversity function of a forest. In the presented research, it was assessed which indices for computing areas, cores and aggregation tendencies that ...
Pirnat, Janez
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Ecosphere, 2018 Numerous studies have focused on the relationship between landscape structure and plant diversity based on the patch‐mosaic landscape paradigm, by deriving structural data from classified images.
José Alberto Gallardo‐Cruz +5 more
doaj +1 more source
Metrics and Energy Landscapes in Irreversible Thermodynamics [PDF]
Entropy, 2015 We describe how several metrics are possible in thermodynamic state space but that only one, Weinhold’s, has achieved widespread use. Lengths calculated based on this metric have been used to bound dissipation in finite-time (irreversible) processes be they continuous or discrete, and described in the energy picture or the entropy picture. Examples are
openaire +4 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Understanding Landscape Structure Using Landscape Metrics
, 2013 Landscape metrics are important tools which are used to understand landscape structure and landscape changes. To use metrics, numeric data is obtained related to landscape structure. Numeric data is produced from satellite images and air photos. Also, landscape metrics are used as compatible with geographical information systems.
openaire +4 more sources