Results 51 to 60 of about 87,651 (259)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
On the effectiveness of multi-scale landscape metrics in soil organic carbon mapping
GeodermaSoil organic carbon (SOC) mapping delivers invaluable information to the global carbon budget and climate change mitigation endeavour. Environmental variables at sample locations are frequently used as explanatory variables for simulating the spatial ...
Jiaxue Wang +7 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Ecosphere, 2018 Numerous studies have focused on the relationship between landscape structure and plant diversity based on the patch‐mosaic landscape paradigm, by deriving structural data from classified images.
José Alberto Gallardo‐Cruz +5 more
doaj +1 more source
Drivers and Metrics for Quantifying IT Landscape Complexity
Mastering complexity is an important topic within the field of Enterprise Architecture (EA), and many companies perceive this as a difficult endeavour due to the growth and perpetual evolution of the Information Technology (IT) landscape. Numerous EA frameworks and methods exist that describe what an IT landscape is.
Eva Stoica +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Studia Universitatis Babeş-Bolyai: Geographia, 2016 Changes in Landscape Metrics Induced by Deforestation in RoOSCI0358 Pricop-Huta-Certeze Nature 2000 Site. The paper analyzes the changes in the landscape structure within the territory of the Site of Community Interest ROSCI0358 Pricop-Huta-Certeze as a
C. CORPADE +5 more
doaj +2 more sources
Analysis of land use and land cover using ecological landscape metrics (case study: Arasbaran region) [PDF]
علوم محیطی, 2018 Introduction: A landscape is a heterogeneous and vast region consisting of a set of patches, habitats, and repetitive environmental elements. In recent studies, various metrics have been used to investigate the structure, function, and landscape pattern ...
Vahid Nasiri, Ali Asghar Darvishsefat
doaj