Results 61 to 70 of about 99,404 (300)

A review of metrics on permutations for search landscape analysis [PDF]

Computers & Operations Research, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Tommaso Schiavinotto, Thomas Stützle
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Using network centrality measures to manage landscape connectivity

, 2008
We use a graph-theoretical landscape modeling approach to investigate how to identify central patches in the landscape as well as how these central patches influence (1) organism movement within the local neighborhood, and (2) the dispersal of organisms ...
Bodin, Orjan, Estrada, Ernesto, Ramon y Cajal program Spain (Funder), , Ramon y Cajal program Spain (Funder), , Swedish Research Council (Funder), Department for Reserch Cooperation, Swedish International Development Cooperation Agency (Funder), Estrada, E., , Swedish Reserach Council for Environment, Agricultural Sciences, Bodin, O., Swedish Reserach Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS) (Funder), Swedish Research Council (Funder), , Department for Reserch Cooperation, Swedish International Develo   +11 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The relative dependence of Spanish landscape pattern on environmental and geographical variables over time

, 2008
The analysis of the dependence of landscape patterns on environment was carried out in order to investigate the landscape structure evolution of Spain. The underlying concept was that the dependence between landscape spatial structure and environmental ...
Ortega Quero, Marta, Bunce, R. G. H., García del Barrio, José, García del Barrio, J. M., Bunce, Robert, Elena-Rosselló, Ramón, Ortega, M., Barrio, J.M.G., del, del Barrio, J.M.G., Bunce, R.G.H., Ortega, Marta, Elena-Rossello, R., Bunce, R. G.H., García Del Barrio, José Manuel   +13 more
core   +1 more source

Visualizing energy landscapes with metric disconnectivity graphs [PDF]

Journal of Computational Chemistry, 2014
The visualization of multidimensional energy landscapes is important, providing insight into the kinetics and thermodynamics of a system, as well the range of structures a system can adopt. It is, however, highly nontrivial, with the number of dimensions required for a faithful reproduction of the landscape far higher than can be represented in two or ...
Lewis C. Smeeton, Mark T. Oakley, Roy L. Johnston   +2 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Behavior of class-level landscape metrics across gradients of class aggregation and area

, 2004
Habitat loss and fragmentation processes strongly affect biodiversity conservation in landscapes undergoing anthropogenic land use changes. Many attempts have been made to use landscape structure metrics to quantify the independent and joint effects of ...
McGarigal, K, Samuel A. Cushman, Cushman, SA, Neel, MC, Kevin Mcgarigal, Maile C. Neel   +5 more
core   +1 more source

Relating species richness to the structure of continuous landscapes: alternative methodological approaches

Ecosphere, 2018
Numerous studies have focused on the relationship between landscape structure and plant diversity based on the patch‐mosaic landscape paradigm, by deriving structural data from classified images.
José Alberto Gallardo‐Cruz, José Luis Hernández‐Stefanoni, Dietmar Moser, Angelina Martínez‐Yrizar, Sergi Llobet, Jorge A. Meave   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source