Results 81 to 90 of about 338,455 (295)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Ekológia (Bratislava), 2017 Agricultural land in many post-socialist countries passed through a similar scenario of eminent changes in the past decades. One of the important milestones was the process of collectivisation (in 1950−1970), transformation to market-oriented economy ...
Masný Matej +2 more
doaj +1 more source
Chaos in Motion: Measuring Visual Pollution with Tangential View Landscape Metrics
Land, 2020 Visual pollution (VP) in the form of outdoor advertisements (OA) is a threat to landscape physiognomy. Despite their proven usefulness in landscape aesthetic studies, landscape metrics have not yet been applied to address the phenomenon of VP.
Szymon Chmielewski
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Adding evidence to the debate: quantifying Airbnb's disruptive impact on ten key hotel markets [PDF]
, 2019 Airbnb's entry into the lodging landscape has dramatically increased the available supply of rooms for accommodating prospective visitors at a destination.
Dogru, Tarik +2 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Cartographic Representation of Averaged Pairwise Information (CRAPI): a new exploratory tool to investigate spatial structures illustrated with genetic data from the Watermelon mosaic virus. [O.15] [PDF]
, 2015 Dedicated analyses in landscape genetics require a priori knowledge on species dispersal abilities. When little is known about the species under study these methods are difficult to apply and, therefore, we rely on exploratory approaches allowing to ...
Berthier, Karine +5 more
core
How to calculate landscape metrics for local landscapes?
, 2020 In the last few weeks, I was asked a similar question several times - how to calculate landscape metrics for local landscapes? In other words, how to divide the categorical input map into a number of smaller areas, and next calculate selected landscape metrics for each of the areas. Those areas have many names, such as tiles, squares, or motifels.
openaire +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source