Results 81 to 90 of about 87,651 (259)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Metrics Toolkit: A Tool For Navigating The Research Metrics Landscape
, 2018 The Metrics Toolkit is an open access resource aimed at helping researchers and evaluators understand and responsibly use research metrics, including bibliometrics and altmetrics. The Toolkit provides evidence-based information about research metrics across disciplines, including how each metric is calculated, where it can be found, and how it should ...
Champieux, Robin +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Assessing the environmental destruction in forest ecosystems using landscape metrics and spatial analysis. [PDF]
Sci Rep, 2023 Mansori M +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
An Assessment of Leporid Research and Landscape Ecology Metrics in a European Landscape [PDF]
Journal of Landscape Ecology, 2013 Abstract Leporids play a dynamic role in the ecosystem and assessments must be undertaken in order to improve research efforts and methods. Landscape ecology metrics are used to quantify components of leporid habitat such as vegetation structure, vegetation cover, habitat type, and fragmentation; however, the degree to which the metrics are ...
openaire +2 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Understanding Landscape Structure Using Landscape Metrics
, 2013 Landscape metrics are important tools which are used to understand landscape structure and landscape changes. To use metrics, numeric data is obtained related to landscape structure. Numeric data is produced from satellite images and air photos. Also, landscape metrics are used as compatible with geographical information systems.
openaire +2 more sources
Application of urban growth boundary delineation based on a neural network approach and landscape metrics for Khulna City, Bangladesh. [PDF]
Heliyon, 2023 Bakshi A, Esraz-Ul-Zannat M.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source