Results 41 to 50 of about 937,052 (303)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

The role of consumer in saving the cultural landscape in the countryside [PDF]

, 2004
The purpose of the study is to observe and to evaluate participation in the land use process and the potential of civil activity in influencing the impacts of planning in the cultural landscape in the ...
Savisalo, Leena
core  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Landscape metrics and indices : an overview of their use in landscape research [PDF]

, 2009
The aim of this overview paper is to analyze the use of various landscape metrics and landscape indices for the characterization of landscape structure and various processes at both landscape and ecosystem level.
Antrop, Marc, Mander, Ülo, Marja, Riho, Roosaare, Jüri, Uuemaa, Evelin   +4 more
core   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Identifying levers of urban neighbourhood transformation using serious games

npj Urban Sustainability
Growing urban population and contemporary urban systems lock-in unsustainable urban development pathways, deteriorating the living quality of urban dwellers.
Johann S. Schuur, Michal Switalski, Nicolas Salliou, Adrienne Grêt-Regamey   +3 more
doaj   +1 more source

Energy poverty from a life cycle sustainability assessment perspective

Cleaner Environmental Systems
Energy poverty (EP) and energy security (ES) are complex, multi-dimensional challenges with profound environmental, economic, and social implications that persist in both developed and developing nations.
T.D. Gates, M. Hannouf, D. Gebremedhin, T.D. Beyene, G. Assefa, I.D. Gates   +5 more
doaj   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

Heritage as a catalyst to enrich communal social capital in rural communities in the Republic of Korea

Built Heritage
The relationship between heritage and social capital remains comparatively underexplored in rural contexts, despite ongoing challenges such as the urban–rural divide, aging populations, and community depopulation.
Minki Sung, Tiancheng Ren, Mustapha Manga   +2 more
doaj   +1 more source

Measuring place rather than space: integrating landscape qualities for the urban–rural gradient using people’s perceptions and machine learning

Journal of Land Use Science
This study applies a generalisable method for measuring place across a large urban-rural landscape by combining subjective and objective data for 7,008 locations in the Utrecht region, the Netherlands. A representative online survey (N = 10,042) was used
Michal Switalski, Maarten Van Strien, Adrienne Grêt-Regamey   +2 more
doaj   +1 more source