Results 41 to 50 of about 946,909 (302)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The 2014 International Planning Competition: Progress and Trends [PDF]

, 2015
We review the 2014 International Planning Competition (IPC-2014), the eighth in a series of competitions starting in 1998. IPC-2014 was held in three separate parts to assess state-of-the-art in three prominent areas of planning research: the ...
Chrpa, Lukas, Editor, Managing, Grześ, Marek, McCluskey, Thomas Leo, Roberts, Mark, Sanner, Scott, Vallati, Mauro   +6 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Mapping human modification and conservation priorities across critical linkages of the Florida Wildlife Corridor

Discover Conservation
The Florida Wildlife Corridor is increasingly affected by intensifying human pressures, leading to cascading environmental changes that threaten ecological integrity and connectivity.
Eve Bohnett, Thomas Hoctor, Michael O’Brien, Elizabeth Thompson, Daniel J. Smith, Kathyrn Frank, Jon Oetting, Reed Noss   +7 more
doaj   +1 more source

Landscape Planning And Management Of Minangkabau Land (Perencanaan dan Pengelolaan Lanskap Minangkabau) [PDF]

, 2005
Dalam Suku Minangkabau, lahan dikelola secara komunal. Unit pengelolaan dilakukan melalui sistem nagari, dimana didalamnya diatur pola penggunaan lahan dan sistem waris.
Kosmaryandi, N. (Nandi)
core  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Identifying levers of urban neighbourhood transformation using serious games

npj Urban Sustainability
Growing urban population and contemporary urban systems lock-in unsustainable urban development pathways, deteriorating the living quality of urban dwellers.
Johann S. Schuur, Michal Switalski, Nicolas Salliou, Adrienne Grêt-Regamey   +3 more
doaj   +1 more source

Energy poverty from a life cycle sustainability assessment perspective

Cleaner Environmental Systems
Energy poverty (EP) and energy security (ES) are complex, multi-dimensional challenges with profound environmental, economic, and social implications that persist in both developed and developing nations.
T.D. Gates, M. Hannouf, D. Gebremedhin, T.D. Beyene, G. Assefa, I.D. Gates   +5 more
doaj   +1 more source

Pylons in the back yard: local planning and perceived risks to health [PDF]

, 2007
Health fears arising from the presence of high-voltage power lines in residential areas have received recent attention in spatial planning. A study of stances taken by planning authorities in England and Wales shows their willingness to give expression ...
Aylesbury Vale District Council, Beck U, Bridgend County Borough Council, Burgess A, Calderdale Metropolitan Borough Council, City and County of Swansea, City of Lincoln Council, Countryside Commission, Cowell R, DETR, DETR, DoH, Giddens A, Goldblatt D, Goulty G, Hansen A, Harremoës P, ICNIRP (International Commission on Non-Ionizing Radiation Protection), IEGMP, LGA, London Borough of Merton, Luckin B, Mendip District Council, Merritt J, National Grid, National Grid, NRPB, National Radiological Protection Board, Didcot, NRPB, National Radiological Protection Board, Didcot, NRPB, National Radiological Protection Board, Didcot, Stephen Jay, Swindon Borough Council, UK CEED, Walker G, WHO, Wynne B   +33 more
core   +1 more source